Prevalence of insulin resistance and its association with metabolic syndrome criteria among Bolivian children and adolescents with obesity.
Prevalence of insulin resistance and its association with metabolic syndrome criteria among Bolivian children and adolescents with obesity.
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DOI：
10.1186/1471-2431-8-31
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发表时间：
2008-08-12
期刊：
影响因子：
2.4
通讯作者：
Medina M
中科院分区：
文献类型：
--
作者：
Caceres M;Teran CG;Rodriguez S;Medina M
肥胖是世界上最常见的营养失调之一，与代谢综合征明显相关，代谢综合征会影响许多慢性疾病的发展。在拉丁美洲最贫穷的国家，营养不良仍然是最普遍的营养问题，但肥胖症在过去十年中以惊人的速度出现，但与代谢综合征之间没有可预测的关联。我们研究的目的是确定一组玻利维亚肥胖儿童和青少年的胰岛素抵抗与代谢综合征成分之间的关联。第二个目标是确定黑棘皮病与胰岛素抵抗的关系。我们研究了 61 名年龄在 5 至 18 岁之间的肥胖儿童和青少年。所有儿童均接受口服葡萄糖耐量试验，并采集空腹血样以测量胰岛素、高密度脂蛋白、低密度脂蛋白和甘油三酯的血清水平。代谢综合征的诊断是根据适用于儿童的国家胆固醇教育计划-成人治疗小组 (NCEP-ATP III) 标准来定义的。 36% 的儿童患有代谢综合征，其中男性 (40%) 的发病率高于女性 (32.2%) (p = 0.599)。每种成分的糖耐量异常患病率为8.2%，高甘油三酯水平为42.6%，低水平高密度脂蛋白胆固醇为55.7%，高血压为24.5%。 39.4%的儿童存在胰岛素抵抗（HOMA-IR > 3.5），其中男性（50%）的比例高于女性（29%）。研究发现胰岛素抵抗与高血压 (p = 0.0148) 和高甘油三酯 (p = 0.002) 之间存在很强的相关性。黑棘皮病的存在与胰岛素抵抗之间没有发现统计学显着性。研究中，代谢综合征在儿童和青少年人群中的患病率为 36%。胰岛素抵抗在肥胖儿童中非常常见，与高血压和高甘油三酯存在显着相关。
Obesity is a one of the most common nutritional disorder worldwide, clearly associated with the metabolic syndrome, condition with implications for the development of many chronic diseases. In the poorest countries of Latin America, malnourishment is still the most prevalent nutritional problem, but obesity is emerging in alarming rates over the last 10 years without a predictable association with metabolic syndrome. The objective of our study was to determine the association between insulin-resistance and components of the metabolic syndrome in a group of Bolivian obese children and adolescents. The second objective was determining the relation of acanthosis nigricans and insulin-resistance. We studied 61 obese children and adolescents aged between 5 and 18 years old. All children underwent an oral glucose tolerance test and fasting blood sample was also obtained to measure insulin, HDL, LDL and triglycerides serum level. The diagnosis of metabolic syndrome was defined according to National Cholesterol Education Program-Adult Treatment Panel (NCEP-ATP III) criteria adapted for children. Metabolic syndrome was found in 36% of the children, with a higher rate among males (40%) than females (32.2%) (p = 0.599). The prevalence of each of the components was 8.2% in impaired glucose tolerance, 42.6% for high triglyceride level, 55.7% for low levels of high-density lipoprotein cholesterol, and 24.5% for high blood pressure. Insulin resistance (HOMA-IR > 3.5) was found in 39.4% of the children, with a higher rate in males (50%) than females (29%). A strong correlation was found between insulin resistance and high blood pressure (p = 0.0148) and high triglycerides (p = 0.002). No statistical significance was found between the presence of acanthosis nigricans and insulin resistance. Metabolic syndrome has a prevalence of 36% in children and adolescent population in the study. Insulin resistance was very common among children with obesity with a significant association with high blood pressure and high triglycerides presence.
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