Medical use, medical misuse, and nonmedical use of prescription opioids: results from a longitudinal study.

Medical use, medical misuse, and nonmedical use of prescription opioids: results from a longitudinal study.
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DOI:
10.1016/j.pain.2013.01.011
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发表时间:
2013-05
期刊:
影响因子:
7.4
通讯作者:
Boyd CJ
Boyd CJ
中科院分区:
医学1区
文献类型:
--
作者:
McCabe SE;West BT;Boyd CJ

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研究与过去一年的医疗使用,医疗滥用和非医疗使用处方阿片类药物(NMUPO)的青少年在两年的时间内,并检查药物滥用,睡眠问题和身体疼痛症状与这些模式的医疗使用,医疗滥用,和NMUPO相关的患病率和模式。在2009-2010年(一年级)和2010-2011年(二年级),对2,050名初中和高中学生进行了一项基于网络的自我调查。密歇根州东南部的两个学区。纵向样本包括50%的女性,67%的白人,28%的非洲裔美国人和5%的其他种族/民族类别。过去一年的医疗使用、医疗误用和NMUPO。在第1年报告适当医疗使用处方阿片类药物的人中,约34%在第2年继续医疗使用。在第1年报告上年NMUPO的人中,约25%在第2年继续NMUPO。适当的医疗使用和NMUPO缓解疼痛在女孩中比男孩更普遍。多元Logistic回归分析表明,与未使用处方阿片类药物的青少年相比,在第1年报告药物滥用或NMUPO用于非疼痛缓解动机的青少年在第2年药物滥用阳性筛查的几率更大。研究结果表明,随着时间的推移,报告医疗滥用或非疼痛缓解动机的青少年药物滥用的风险增加。这一发现对减少青少年药物滥用和NMUPO的干预措施具有重要的临床意义。
To examine the prevalence and patterns associated with past-year medical use, medical misuse, and nonmedical use of prescription opioids (NMUPO) among adolescents over a two-year time period and to examine substance abuse, sleeping problems, and physical pain symptoms associated with these patterns of medical use, medical misuse, and NMUPO. A Web-based survey was self-administered by a longitudinal sample of 2,050 middle and high school students in 2009–2010 (Year 1) and again in 2010–2011 (Year 2). Two southeastern Michigan school districts. The longitudinal sample consisted of 50% females, 67% Whites, 28% African- Americans, and 5% from other racial/ethnic categories. Past-year medical use, medical misuse, and NMUPO. Of those reporting appropriate medical use of prescription opioids in Year 1, approximately 34% continued medical use in Year 2. Of those reporting past-year NMUPO in Year 1, approximately 25% continued NMUPO in Year 2. Appropriate medical use and NMUPO for pain relief was more prevalent among girls than boys. Multiple logistic regression analyses indicated that the odds of a positive screen for substance abuse in Year 2 were greater for adolescents who reported medical misuse or NMUPO for non-pain relief motives in Year 1 compared with those who did not use prescription opioids. The findings indicate an increased risk for substance abuse among adolescents who report medical misuse or NMUPO for non-pain relief motives over time. The findings have important clinical implications for interventions to reduce medical misuse and NMUPO among adolescents.
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