SIRT2 is involved in the modulation of depressive behaviors.
SIRT2 is involved in the modulation of depressive behaviors.
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DOI：
10.1038/srep08415
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发表时间：
2015-02-12
影响因子：
4.6
通讯作者：
Liu Z
中科院分区：
文献类型：
--
作者：
Liu R;Dang W;Du Y;Zhou Q;Jiao K;Liu Z
暴露于慢性压力会对情绪和依赖于校园的记忆形成产生负面影响。SIRT2的改变已被报道在情绪障碍;然而，SIRT2在抑郁症中的作用仍不清楚。因此，我们的目的是确定SIRT2是否可以恢复应激诱导的神经发生抑制大鼠慢性不可预测的压力（CUS）抑郁症模型。采用蔗糖偏好实验、笼内活动实验、强迫游泳实验和高架十字迷宫实验检测SIRT 2在CUS模型中的作用。为了进一步确定海马神经发生是否参与了SIRT介导的抗抑郁样行为，采用X射线照射大鼠以破坏海马神经发生过程。CUS降低海马SIRT2蛋白的表达。抗抑郁药氟西汀治疗逆转了抑郁症诱导的SIRT2变化。此外，通过tenovin-D3抑制SIRT2导致大鼠抑郁样行为和海马神经发生受损。相反，通过海马内输注表达小鼠SIRT2的重组腺病毒载体来过度表达SIRT2，逆转了海马神经元诱导的抑郁样行为，并促进了神经发生。通过X射线照射破坏齿状回的神经发生消除了Ad-SIRT2-GFP的抗抑郁样作用。这些发现表明，海马SIRT2参与抑郁样行为的调制，可能通过调节神经发生。
Exposure to chronic stress produces negative effects on mood and hippocampus-dependent memory formation. SIRT2 alteration has been reported in mood disorders; however, the role of SIRT2 in depression remains unclear. Therefore, we aimed to determine whether SIRT2 can restore stress-induced suppression of neurogenesis in a rat chronic unpredictable stress (CUS) model of depression. Sucrose preference test, home-cage locomotion, forced swim test, and elevated plus maze were used to determine the role of SIRT2 in CUS model. To further determine the hippocampal neurogenesis contributes to the role of SIRT in mediating the antidepressant-like behavior, rats were exposed to X-irradiation to disrupt the process of hippocampal neurogenesis. CUS decreased expression of the SIRT2 protein in the hippocampus. Treatment with the antidepressant fluoxetine reversed the CUS-induced SIRT2 change. Furthermore, inhibiting SIRT2 by tenovin-D3 resulted in depression-like behaviors and impaired hippocampal neurogenesis in rats. Conversely, overexpression of SIRT2 by the intra-hippocampal infusion of recombinant adenovirus vector expressing mouse SIRT2 reversed the CUS-induced depressive-like behaviors, and promoted neurogenesis. Disrupting neurogenesis in the dentate gyrus by X-irradiation abolished the antidepressant-like effect of Ad-SIRT2-GFP. These findings indicate that hippocampal SIRT2 is involved in the modulation of depressant-like behaviors, possibly by regulating neurogenesis.
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DOI：
10.1523/jneurosci.1758-09.2009
发表时间：
2009-09-16
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Covington HE 3rd;Maze I;LaPlant QC;Vialou VF;Ohnishi YN;Berton O;Fass DM;Renthal W;Rush AJ 3rd;Wu EY;Ghose S;Krishnan V;Russo SJ;Tamminga C;Haggarty SJ;Nestler EJ
通讯作者：
Nestler EJ
影响因子：
2.7
作者：
Egan, Rupert J.;Bergner, Carisa L.;Hart, Peter C.;Cachat, Jonathan M.;Canavello, Peter R.;Elegante, Marco F.;Elkhayat, Salem I.;Bartels, Brett K.;Tien, Anna K.;Tien, David H.;Mohnot, Sopan;Beeson, Esther;Glasgow, Eric;Amri, Hakima;Zukowska, Zofia;Kalueff, Allan V.
通讯作者：
Kalueff, Allan V.
影响因子：
10.6
作者：
Miller, Andrew H.;Maletic, Vladimir;Raison, Charles L.
通讯作者：
Raison, Charles L.
DOI：
10.3988/jcn.2009.5.3.120
发表时间：
2009-09
期刊：
Journal of clinical neurology (Seoul, Korea)
影响因子：
--
作者：
Han SH
通讯作者：
Han SH
影响因子：
5.3
作者：
van Praag, H;Shubert, T;Gage, FH
通讯作者：
Gage, FH