Implications of Systemic Inflammation and Periodontitis for Major Depression.
Implications of Systemic Inflammation and Periodontitis for Major Depression.
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DOI：
10.3389/fnins.2018.00483
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发表时间：
2018
影响因子：
4.3
通讯作者：
Miyaoka T
中科院分区：
文献类型：
--
作者：
Hashioka S;Inoue K;Hayashida M;Wake R;Oh-Nishi A;Miyaoka T
越来越多的证据表明，外周组织感染和持续低度炎症是重性抑郁症的重要致病因素。重度抑郁症通常与系统性炎症性疾病/病症合并症，如类风湿关节炎、不同类型的过敏、多发性硬化症、心血管疾病、炎症性肠病、慢性肝病、糖尿病和癌症，在这些疾病中，促炎细胞因子过度表达。许多动物研究表明，外周给药脂多糖引起的全身性炎症增加了外周和大脑中促炎细胞因子的表达，并导致类似于重度抑郁症的异常行为。全身性炎症可通过几种假定的途径引起中枢神经系统中与神经胶质激活相关的促炎细胞因子水平的增加，即神经炎症。这种神经炎症反过来又会通过影响与重度抑郁症相关的大脑功能，尤其是神经递质代谢，诱发抑郁情绪和行为改变。尽管各种临床研究暗示牙周炎（成人中最常见的慢性炎症性疾病之一）与重度抑郁症之间存在因果关系，但牙周炎是重度抑郁症的危险因素这一概念仍未得到证实。需要更多的基于人群的队列研究或关于牙周炎和重度抑郁之间关系的前瞻性临床研究来证实牙周炎和重度抑郁的因果关系。如果建立了这样的联系，牙周炎可能通过简单的预防性口腔治疗成为严重抑郁症的一个可改变的危险因素。
Increasing evidence suggests that infection and persistent low-grade inflammation in peripheral tissues are important pathogenic factors in major depression. Major depression is frequently comorbid with systemic inflammatory diseases/conditions such as rheumatoid arthritis, allergies of different types, multiple sclerosis, cardiovascular disease, inflammatory bowel disease, chronic liver disease, diabetes, and cancer, in which pro-inflammatory cytokines are overexpressed. A number of animal studies demonstrate that systemic inflammation induced by peripheral administration of lipopolysaccharide increases the expression of pro-inflammatory cytokines in both the periphery and brain and causes abnormal behavior similar to major depression. Systemic inflammation can cause an increase in CNS levels of pro-inflammatory cytokines associated with glial activation, namely, neuroinflammation, through several postulated pathways. Such neuroinflammation can in turn induce depressive moods and behavioral changes by affecting brain functions relevant to major depression, especially neurotransmitter metabolism. Although various clinical studies imply a causal relationship between periodontitis, which is one of the most common chronic inflammatory disorders in adults, and major depression, the notion that periodontitis is a risk factor for major depression is still unproven. Additional population-based cohort studies or prospective clinical studies on the relationship between periodontitis and major depression are needed to substantiate the causal link of periodontitis to major depression. If such a link is established, periodontitis may be a modifiable risk factor for major depression by simple preventive oral treatment.
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影响因子：
3.1
作者：
Arauchi R;Hashioka S;Tsuchie K;Miyaoka T;Tsumori T;Limoa E;Azis IA;Oh-Nishi A;Miura S;Otsuki K;Kanayama M;Izuhara M;Nagahama M;Kawano K;Araki T;Liaury K;Abdullah RA;Wake R;Hayashida M;Inoue K;Horiguchi J
通讯作者：
Horiguchi J
影响因子：
--
作者：
Dantzer R
通讯作者：
Dantzer R
影响因子：
4.6
作者：
Biesmans S;Meert TF;Bouwknecht JA;Acton PD;Davoodi N;De Haes P;Kuijlaars J;Langlois X;Matthews LJ;Ver Donck L;Hellings N;Nuydens R
通讯作者：
Nuydens R
影响因子：
2.5
作者：
Bayer, TA;Buslei, R;Falkai, P
通讯作者：
Falkai, P
影响因子：
7.6
作者：
Godbout, Jonathan P.;Moreau, Maite;Johnson, Rodney W.
通讯作者：
Johnson, Rodney W.