Surface modification strategies to improve titanium hemocompatibility: a comprehensive review.
Surface modification strategies to improve titanium hemocompatibility: a comprehensive review.
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DOI：
10.1039/d1ma00367d
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发表时间：
2021-09-20
影响因子：
5
通讯作者：
Popat KC
中科院分区：
文献类型：
--
作者：
Manivasagam VK;Sabino RM;Kantam P;Popat KC
钛及钛合金具有优异的力学性能和生物惰性，被广泛应用于各种生物材料中。然而，钛基材料仍然面临着一些挑战，重点是血液相容性。由于不适当的血液-植入物表面相互作用，血液接触器械（如支架、心脏瓣膜和循环器械）易于形成血栓、再狭窄和炎症。植入后，当血液遇到这些植入物表面时，会发生一系列反应，如蛋白质吸附、血小板粘附和活化，以及形成白色血细胞复合物作为防御机制。目前，患者被处方抗凝药物以防止血液凝固，但这些药物会削弱他们的免疫系统，并在受伤时引起严重出血。为了提高钛的血液相容性，人们对钛的表面改性进行了广泛的研究。结果表明，表面形态、粗糙度和化学性质的改变可有效减少血栓形成。本综述的主要重点是分析和了解钛基表面上的不同改性技术，以提高血液相容性，从而认识到尚未解决的挑战，并提出未来的研究范围。本文旨在探索钛表面的血液相容性，以延长植入物寿命。研究的表面处理技术表明，不同的表面性能可以调整，以提高血液相容性。
Titanium and its alloys are widely used in different biomaterial applications due to their remarkable mechanical properties and bio-inertness. However, titanium-based materials still face some challenges, with an emphasis on hemocompatibility. Blood-contacting devices such as stents, heart valves, and circulatory devices are prone to thrombus formation, restenosis, and inflammation due to inappropriate blood–implant surface interactions. After implantation, when blood encounters these implant surfaces, a series of reactions takes place, such as protein adsorption, platelet adhesion and activation, and white blood cell complex formation as a defense mechanism. Currently, patients are prescribed anticoagulant drugs to prevent blood clotting, but these drugs can weaken their immune system and cause profound bleeding during injury. Extensive research has been done to modify the surface properties of titanium to enhance its hemocompatibility. Results have shown that the modification of surface morphology, roughness, and chemistry has been effective in reducing thrombus formation. The main focus of this review is to analyze and understand the different modification techniques on titanium-based surfaces to enhance hemocompatibility and, consequently, recognize the unresolved challenges and propose scopes for future research. This manuscript aims to explore the hemocompatibility of titanium surfaces for achieving enhanced implant life. The surface treatment techniques investigated have shown that different surface properties can be tuned to improve hemocompatibility.
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DOI：
10.1007/s10856-019-6270-6
发表时间：
2019-06-04
期刊：
Journal of materials science. Materials in medicine
影响因子：
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影响因子：
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