Enhancing targeted tumor treatment by near IR light-activatable photodynamic-photothermal synergistic therapy.
Enhancing targeted tumor treatment by near IR light-activatable photodynamic-photothermal synergistic therapy.
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DOI：
10.1021/mp4002816
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发表时间：
2014-04-07
影响因子：
4.9
通讯作者：
Ray PC
中科院分区：
文献类型：
--
作者：
Fan Z;Dai X;Lu Y;Yu E;Brahmbatt N;Carter N;Tchouwou C;Singh AK;Jones Y;Yu H;Ray PC
几十年来，癌症一直是最威胁生命的疾病之一。为了在副作用最小的情况下提高抗癌效率，设想了联合治疗。目前的手稿首次报道了亚甲基蓝（MB）结合纳米平台的开发，该平台能够提供癌症的靶向诊断和联合协同光热和光动力治疗。实验数据发现，一旦纳米颗粒与靶细胞表面结合，它可以使用荧光成像选择性地检测LNCaP人前列腺癌细胞。我们的结果表明，治疗作用可以通过外部近红外光来控制。在不存在NIR光的情况下未观察到细胞毒性。使用785 nm NIR光的靶向光动力学和光热治疗表明，多模式治疗显著提高了体外破坏LNCaP前列腺癌细胞的可能性。我们讨论了靶向成像的工作原理和联合治疗作用的可能机制。我们的实验数据表明，近红外光激活的癌症联合治疗可能成为一个非常有效的治疗程序，在临床设置。
For several decades, cancer has been one of the most life-threatening diseases. For enhancing anticancer efficiency with minimum side effects, combination therapy is envisioned. The current manuscript reports for the first time the development of a methylene blue (MB) bound nanoplatform, which is capable of delivering targeted diagnostic and combined synergistic photothermal and photodynamic treatment of cancer. Experimental data found that, once the nanoparticle binds with the target cell surface, it can detect LNCaP human prostate cancer cell selectively using fluorescence imaging. Our result shows that the therapeutic actions can be controlled with external NIR light. No cytotoxicity was observed in the absence of NIR light. Targeted photodynamic and photothermal treatment using 785 nm NIR light indicates that the multimodal treatment enhances the possibility of destroying LNCaP prostate cancer cells in vitro dramatically. We discuss the operating principle for the targeted imaging and possible mechanisms for combined therapeutic actions. Our experimental data show that NIR light activated combined therapy for cancer may become a highly effective treatment procedure in clinical settings.
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使用简单的比色和高灵敏度双光子散射测定法，基于多功能椭圆形金纳米粒子选择性检测乳腺癌细胞。
影响因子：
17.1
作者：
Lu, Wentong;Arumugam, Ranjini;Senapati, Dulal;Singh, Anant K.;Arbneshi, Tahir;Khan, Sadia Afrin;Yu, Hongtao;Ray, Paresh Chandra
通讯作者：
Ray, Paresh Chandra
影响因子：
29.4
作者：
Park, Ji-Ho;von Maltzahn, Geoffrey;Ong, Luvena L.;Centrone, Andrea;Hatton, T. Alan;Ruoslahti, Erkki;Bhatia, Sangeeta N.;Sailor, Michael J.
通讯作者：
Sailor, Michael J.
影响因子：
4.9
作者：
Ganta, Srinivas;Amiji, Mansoor
通讯作者：
Amiji, Mansoor
影响因子：
--
作者：
Noimark, Sacha;Dunnill, Charles W.;Parkin, Ivan P.
通讯作者：
Parkin, Ivan P.
影响因子：
16.6
作者：
Liu, Huiyu;Chen, Dong;Tang, Fangqiong
通讯作者：
Tang, Fangqiong