Epidemiology and etiology of meningioma.
Epidemiology and etiology of meningioma.
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DOI：
10.1007/s11060-010-0386-3
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发表时间：
2010-09
影响因子：
3.9
通讯作者：
Claus EB
中科院分区：
文献类型：
--
作者：
Wiemels J;Wrensch M;Claus EB
尽管大多数脑膜瘤是有包膜的良性肿瘤，遗传异常的数量有限，但其位于颅内的位置往往会导致严重的和潜在的致命后果。它们是2002年至2006年美国报告的最常见的原发脑肿瘤，占所有原发脑肿瘤和中枢神经系统肿瘤的33.8%。家族史和DNA修复基因的候选基因研究都表明脑膜瘤的遗传易感性。具有神经纤维瘤病基因(NF2)特定突变的人患脑膜瘤的风险大大增加。高剂量电离辐射暴露是脑膜瘤的既定危险因素，低剂量也可能增加风险，但哪些类型和剂量存在争议或研究不足。由于女性患脑膜瘤的可能性是男性的两倍，而且这些肿瘤含有激素受体，因此激素(包括内源性和外源性)在病因学上的作用已经被假设。免疫因素对脑膜瘤病因的影响程度在很大程度上尚不清楚。对脑肿瘤研究的日益重视，加上遗传学和分子流行病学中新的遗传和分子流行病学工具的出现，有望促进对颅内脑膜瘤病因的了解。在这篇综述中，我们强调了关于脑膜瘤流行病学和病因学的现有知识，并提出了未来的研究方向。
Although most meningiomas are encapsulated and benign tumors with limited numbers of genetic aberrations, their intracranial location often leads to serious and potentially lethal consequences. They are the most frequently diagnosed primary brain tumor accounting for 33.8% of all primary brain and central nervous system tumors reported in the United States between 2002 and 2006. Inherited susceptibility to meningioma is suggested both by family history and candidate gene studies in DNA repair genes. People with certain mutations in the neurofibromatosis gene (NF2) have a very substantial increased risk for meningioma. High dose ionizing radiation exposure is an established risk factor for meningioma, and lower doses may also increase risk, but which types and doses are controversial or understudied. Because women are twice as likely as men to develop meningiomas and these tumors harbor hormone receptors, an etiologic role for hormones (both endogenous and exogenous) has been hypothesized. The extent to which immunologic factors influence meningioma etiology has been largely unexplored. Growing emphasis on brain tumor research coupled with the advent of new genetic and molecular epidemiologic tools in genetic and molecular epidemiology promise hope for advancing knowledge about the causes of intra-cranial meningioma. In this review, we highlight current knowledge about meningioma epidemiology and etiology and suggest future research directions.
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影响因子：
3.9
作者：
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通讯作者：
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