Weight cycling enhances adipose tissue inflammatory responses in male mice.
Weight cycling enhances adipose tissue inflammatory responses in male mice.
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DOI：
10.1371/journal.pone.0039837
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发表时间：
2012
期刊：
影响因子：
3.7
通讯作者：
Aguila MB
中科院分区：
文献类型：
--
作者：
Barbosa-da-Silva S;Fraulob-Aquino JC;Lopes JR;Mandarim-de-Lacerda CA;Aguila MB
肥胖与低度慢性炎症有关，这些炎症归因于细胞因子和脂肪因子的产生、释放失调以及葡萄糖-胰岛素稳态失调和血脂异常。营养干预，如节食，往往伴随着反复发作的体重减轻和恢复，这种现象被称为体重循环（WC）。在这项工作中，我们研究了WC对饲料效率，血脂，碳水化合物代谢，肥胖和炎症标志物的C57 BL/6雄性小鼠，WC连续两次或三次，交替的高脂肪（HF）饮食与标准食物（SC）。体质量（BM）在HF喂养的每个周期中增长，在SC喂养的每个周期后下降。在口服葡萄糖耐量试验、血脂、血清和脂肪组织脂肪因子表达中观察到的喂食HF饮食的动物的改变在WC后没有恢复。此外，HF喂养时间越长（2个月、4个月和6个月），肥胖越严重。在连续三次WC后，SC喂养期间BM减少不太明显，而HF喂养期间BM增加更严重。总之，本研究的结果表明，HF饮食和WC都与小鼠的BM演变和脂肪垫重塑有关，并对血脂、葡萄糖-胰岛素和脂肪因子水平的稳态产生影响。WC期间BM的简单减少不能恢复血清和脂肪组织中高水平的脂肪因子以及HF饮食周期期间增强的促炎细胞因子。这些发现是重要的，因为与WC相关的改变的脂肪因子的环境潜在地加重了归因于小鼠中脂肪因子的失调产生和释放的慢性炎症。
Obesity is associated with low-grade chronic inflammation attributed to dysregulated production, release of cytokines and adipokines and to dysregulated glucose-insulin homeostasis and dyslipidemia. Nutritional interventions such as dieting are often accompanied by repeated bouts of weight loss and regain, a phenomenon known as weight cycling (WC). In this work we studied the effects of WC on the feed efficiency, blood lipids, carbohydrate metabolism, adiposity and inflammatory markers in C57BL/6 male mice that WC two or three consecutive times by alternation of a high-fat (HF) diet with standard chow (SC). The body mass (BM) grew up in each cycle of HF feeding, and decreased after each cycle of SC feeding. The alterations observed in the animals feeding HF diet in the oral glucose tolerance test, in blood lipids, and in serum and adipose tissue expression of adipokines were not recuperated after WC. Moreover, the longer the HF feeding was (two, four and six months), more severe the adiposity was. After three consecutive WC, less marked was the BM reduction during SC feeding, while more severe was the BM increase during HF feeding. In conclusion, the results of the present study showed that both the HF diet and WC are relevant to BM evolution and fat pad remodeling in mice, with repercussion in blood lipids, homeostasis of glucose-insulin and adipokine levels. The simple reduction of the BM during a WC is not able to recover the high levels of adipokines in the serum and adipose tissue as well as the pro-inflammatory cytokines enhanced during a cycle of HF diet. These findings are significant because a milieu with altered adipokines in association with WC potentially aggravates the chronic inflammation attributed to dysregulated production and release of adipokines in mice.
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影响因子：
--
作者：
FAUST, IM;JOHNSON, PR;HIRSCH, J
通讯作者：
HIRSCH, J
影响因子：
6.9
作者：
Ahima, Rexford S.
通讯作者：
Ahima, Rexford S.
影响因子：
4.4
作者：
Catta-Preta, Mariana;Martins, Marcela Anjos;Aguila, Marcia Barbosa
通讯作者：
Aguila, Marcia Barbosa
影响因子：
7.1
作者：
Heitmann, BL;Garby, L
通讯作者：
Garby, L
影响因子：
1.9
作者：
JOLICOEUR, P;HEUSNER, AA
通讯作者：
HEUSNER, AA