SIRT1 genetic variation is related to BMI and risk of obesity.
SIRT1 genetic variation is related to BMI and risk of obesity.
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DOI：
10.2337/db09-0536
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发表时间：
2009-12
期刊：
影响因子：
7.7
通讯作者：
Uitterlinden AG
中科院分区：
文献类型：
--
作者：
Zillikens MC;van Meurs JB;Rivadeneira F;Amin N;Hofman A;Oostra BA;Sijbrands EJ;Witteman JC;Pols HA;van Duijn CM;Uitterlinden AG
SIRT 1具有多种代谢功能。我们研究了SIRT 1基因变异是否与肥胖相关。在来自前瞻性、基于人群的鹿特丹研究的6，251名老年受试者中，研究了SIRT 1基因中的三个单核苷酸多态性（SNP）与BMI和肥胖风险（BMI ≥30 kg/m2）的关系，并前瞻性地研究了6.4年随访后BMI的变化。我们使用来自伊拉斯谟鲁克芬家族（ERF）研究的2,347名参与者的横断面数据进行复制。rs7895833的次要等位基因（G = 20.2%）和rs 1467568（A = 36.8%）与鹿特丹研究中较低的BMI相关（P = 0.02和0.04），在重复队列ERF研究中（P = 0.03和0.008），并在两项研究相结合（P = 0.002的两个SNP），与0.2-0.4 kg/m2的BMI降低每个等位基因拷贝。这些等位基因的携带者患肥胖症的风险降低了13-18%（鹿特丹研究中rs7895833：比值比0.79 [95% CI 0.67-0.94]，P = 0.007; ERF研究中：0.93 [0.73-1.19]，P = 0.37;合并研究中为0.87 [0.77-0.97]，P = 0.02;鹿特丹研究中rs 1467568：0.80 [0.68-0.94]，P = 0.007; ERF研究中：0.85 [0.72-0.99]，P = 0.04;合并研究中：0.82 [0.73-0.92]，P = 0.0009）。在鹿特丹研究中，这两种变体也与6.4年随访期间较低的BMI增加相关（P = 0.01和0.08）。在两个独立的荷兰人群中，SIRT 1的两种常见变异与较低的BMI相关。这些变异的携带者患肥胖症的风险降低了13-18%，并且随着时间的推移体重增加较少。SIRT 1刺激剂的可用性使得这些发现与日益增长的肥胖流行病有关。
SIRT1 has pleiotropic metabolic functions. We investigated whether SIRT1 genetic variation is associated with obesity. In 6,251 elderly subjects from the prospective, population-based Rotterdam Study, three single nucleotide polymorphisms (SNPs) in the SIRT1 gene were studied in relation to BMI and risk of obesity (BMI ≥30 kg/m2) and prospectively with BMI change after 6.4 years of follow-up. We used cross-sectional data from 2,347 participants from the Erasmus Rucphen Family (ERF) study for replication. Minor alleles of rs7895833 (G = 20.2%) and rs1467568 (A = 36.8%) were associated with lower BMI in the Rotterdam Study (P = 0.02 and 0.04) and in the replication cohort ERF study (P = 0.03 and 0.008) and in both studies combined (P = 0.002 for both SNPs), with a 0.2–0.4 kg/m2 decrease in BMI per allele copy. Carriers of these alleles had 13–18% decreased risk of obesity (for rs7895833 in the Rotterdam Study: odds ratio 0.79 [95% CI 0.67–0.94], P = 0.007; in the ERF study: 0.93 [0.73–1.19], P = 0.37; and in the studies combined 0.87 [0.77–0.97], P = 0.02; for rs1467568 in the Rotterdam Study: 0.80 [0.68–0.94], P = 0.007; in the ERF study: 0.85 [0.72–0.99], P = 0.04; and in the studies combined: 0.82 [0.73–0.92], P = 0.0009). In the Rotterdam Study, the two variants were also associated with a lower BMI increase during 6.4 years of follow-up (P = 0.01 and 0.08). Two common variants in SIRT1 are associated with lower BMI in two independent Dutch populations. Carriers of these variants have 13–18% decreased risk of obesity and gain less weight over time. The availability of SIRT1 stimulators makes these findings relevant in light of the growing obesity epidemic.
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影响因子：
64.8
作者：
Handschin, Christoph;Spiegelman, Bruce M.
通讯作者：
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