Understanding the asthmatic response to an experimental rhinovirus infection: Exploring the effects of blocking IgE.
Understanding the asthmatic response to an experimental rhinovirus infection: Exploring the effects of blocking IgE.
复制标题
DOI：
10.1016/j.jaci.2020.01.035
复制
发表时间：
2020-09
期刊：
影响因子：
--
通讯作者：
Turner RB
中科院分区：
文献类型：
--
作者：
Heymann PW;Platts-Mills TAE;Woodfolk JA;Borish L;Murphy DD;Carper HT;Conaway MR;Steinke JW;Muehling L;Gerald Teague W;Kennedy JL;Irani AM;McGraw MD;Early SV;Wheatley LM;Adams AP;Turner RB
鼻病毒经常导致过敏儿童和年轻人哮喘加重。随着时间的推移，过敏原和鼻病毒引起的症状和炎症之间的相互作用尚不清楚。我们的目的是比较过敏性哮喘患者实验性接种 rhinovirus-16 的反应与健康对照的反应，并评估感染前和感染期间施用奥马珠单抗的效果。两项临床试验同时进行。在其中一项试验中，总 IgE 水平较高的哮喘患者对鼻病毒 16 实验性接种的反应与健康对照的反应进行了比较。另一项试验在一项随机、双盲安慰剂对照研究中比较了奥马珠单抗与安慰剂对哮喘患者的影响。这两项试验的主要结果比较了感染前 4 天各研究组之间的下呼吸道症状 (LRTS)。对症状、肺功能和血液嗜酸性粒细胞计数的频繁比较显示，在病毒接种后第 2 天和第 3 天，过敏性哮喘患者的差异比对照组更明显。此外，在症状消退期间，与对照组相比，特应性哮喘患者的上呼吸道症状评分和 LRTS 评分有所增加（上呼吸道症状评分 P < .01，LRTS 评分 P < .001）。服用奥马珠单抗对减少 LRTS 和改善肺功能的有益效果在前 4 天内最强。过敏性哮喘患者在接种鼻病毒后早期，LRTS 和血液嗜酸性粒细胞计数增加，肺功能降低，但在感染后期症状消退期间增加。给予奥马珠单抗对鼻病毒反应的影响在感染的早期/先天阶段最为明显。
Rhinovirus frequently causes asthma exacerbations among children and young adults who are allergic. The interaction between allergen and rhinovirus-induced symptoms and inflammation over time is unclear. Our aim was to compare the response to an experimental inoculation with rhinovirus-16 in allergic asthmatics with the response in healthy controls and to evaluate the effects of administrating omalizumab before and during the infection. Two clinical trials were run in parallel. In one of these trials, the response to an experimental inoculation with rhinovirus-16 among asthmatics with high levels of total IgE was compared to the response in healthy controls. The other trial compared the effects of administering omalizumab versus placebo to asthmatics in a randomized, double-blind placebo-controlled investigation. The primary outcome for both trials compared lower respiratory tract symptoms (LRTSs) between study groups over the first 4 days of infection. Frequent comparisons of symptoms, lung function, and blood eosinophil counts revealed differences that were more pronounced among allergic asthmatics than among controls by days 2 and 3 after virus inoculation. Additionally, an augmentation of upper respiratory tract symptom scores and LRTS scores occurred among the atopic asthmatics versus the controls during the resolution of symptoms (P < .01 for upper respiratory symptom tract scores and P < .001 for LRTS scores). The beneficial effects of administering omalizumab on reducing LRTSs and improving lung function were strongest over the first 4 days. LRTSs and blood eosinophil counts were augmented and lung function was reduced among allergic asthmatics early after rhinovirus inoculation but increased late in the infection during symptom resolution. The effect of administering omalizumab on the response to rhinovirus was most pronounced during the early/innate phase of the infection.
登录
查看更多内容
影响因子：
14.2
作者：
Soto-Quiros, Manuel;Avila, Lydiana;Platts-Mills, Thomas A. E.;Hunt, John F.;Erdman, Dean D.;Carper, Holliday;Murphy, Deborah D.;Odio, Silvia;James, Hayley R.;Patrie, James T.;Hunt, William;O'Rourke, Ashli K.;Davis, Michael D.;Steinke, John W.;Lu, Xiaoyan;Kennedy, Joshua;Heymann, Peter W.
通讯作者：
Heymann, Peter W.
DOI：
10.1164/rccm.201803-0461oc
发表时间：
2019-02-15
影响因子：
24.7
作者：
Pineros, Yanaika S. Sabogal;Bal, Suzanne M.;Lutter, Rene
通讯作者：
Lutter, Rene
DOI：
10.1164/ajrccm.159.3.9801052
发表时间：
1999-03-01
影响因子：
24.7
作者：
Rakes, CP;Arruda, E;Heymann, PW
通讯作者：
Heymann, PW
影响因子：
9.4
作者：
Arruda, E;Crump, CE;Hayden, FG
通讯作者：
Hayden, FG
影响因子：
6.1
作者：
Agrawal, R.;Wisniewski, J.;Woodfolk, J. A.
通讯作者：
Woodfolk, J. A.