High titers of IgE antibody to dust mite allergen and risk for wheezing among asthmatic children infected with rhinovirus.
High titers of IgE antibody to dust mite allergen and risk for wheezing among asthmatic children infected with rhinovirus.
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DOI：
10.1016/j.jaci.2012.03.040
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发表时间：
2012-06
影响因子：
14.2
通讯作者：
Heymann, Peter W.
中科院分区：
文献类型：
--
作者：
Soto-Quiros, Manuel;Avila, Lydiana;Platts-Mills, Thomas A. E.;Hunt, John F.;Erdman, Dean D.;Carper, Holliday;Murphy, Deborah D.;Odio, Silvia;James, Hayley R.;Patrie, James T.;Hunt, William;O'Rourke, Ashli K.;Davis, Michael D.;Steinke, John W.;Lu, Xiaoyan;Kennedy, Joshua;Heymann, Peter W.
关键词：
根据血清 IgE 抗体滴度判断，过敏致敏与鼻病毒引起的哮喘恶化风险之间的相关性尚不清楚。我们试图研究哥斯达黎加鼻病毒感染的患病率与接受喘息治疗的儿童特应性状态之间的关系，哥斯达黎加是一个哮喘负担增加的国家。登记的儿童 (n = 287) 年龄为 7 岁至 12 岁。其中包括 96 名患有急性喘息的受试者、65 名患有稳定哮喘的受试者以及 126 名非哮喘对照受试者。 PCR方法，包括基因测序来鉴定鼻病毒株，被用来鉴定鼻洗液中的病毒病原体。检查结果与喘息、IgE、过敏原特异性 IgE 抗体和呼出一氧化氮水平分数的关系。 64% 的喘息儿童、13% 的哮喘稳定儿童和 13% 的非哮喘对照受试者的鼻病毒检测结果呈阳性（两项比较 P < .001）。在喘息受试者中，检测到的鼻病毒中 75% 是 C 组病毒株。尘螨过敏原（尤其是螨类）的高滴度 IgE 抗体很常见，并且与总 IgE 和呼出一氧化氮水平显着相关。尘螨 IgE 抗体滴度为 17.5 IU/mL 或更高且鼻病毒检测呈阳性的儿童出现喘息的风险最大（喘息比值比，31.5；95% CI，8.3-108；P < .001）。哮喘儿童中，针对尘螨过敏原的高滴度 IgE 抗体很常见，并且显着增加了由鼻病毒引起的急性喘息的风险。
The relevance of allergic sensitization, as judged by titers of serum IgE antibodies, to the risk of an asthma exacerbation caused by rhinovirus is unclear. We sought to examine the prevalence of rhinovirus infections in relation to the atopic status of children treated for wheezing in Costa Rica, a country with an increased asthma burden. The children enrolled (n = 287) were 7 through 12 years old. They included 96 with acute wheezing, 65 with stable asthma, and 126 nonasthmatic control subjects. PCR methods, including gene sequencing to identify rhinovirus strains, were used to identify viral pathogens in nasal washes. Results were examined in relation to wheezing, IgE, allergen-specific IgE antibody, and fraction of exhaled nitric oxide levels. Sixty-four percent of wheezing children compared with 13% of children with stable asthma and 13% of nonasthmatic control subjects had positive test results for rhinovirus (P < .001 for both comparisons). Among wheezing subjects, 75% of the rhinoviruses detected were group C strains. High titers of IgE antibodies to dust mite allergen (especially Dermatophagoides species) were common and correlated significantly with total IgE and fraction of exhaled nitric oxide levels. The greatest risk for wheezing was observed among children with titers of IgE antibodies to dust mite of 17.5 IU/mL or greater who tested positive for rhinovirus (odds ratio for wheezing, 31.5; 95% CI, 8.3-108; P < .001). High titers of IgE antibody to dust mite allergen were common and significantly increased the risk for acute wheezing provoked by rhinovirus among asthmatic children.
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DOI：
10.1183/09031936.00092410
发表时间：
2011-05
期刊：
The European respiratory journal
影响因子：
--
作者：
Bizzintino J;Lee WM;Laing IA;Vang F;Pappas T;Zhang G;Martin AC;Khoo SK;Cox DW;Geelhoed GC;McMinn PC;Goldblatt J;Gern JE;Le Souëf PN
通讯作者：
Le Souëf PN
影响因子：
14.2
作者：
Jackson, Daniel J.;Virnig, Christine M.;Gangnon, Ronald E.;Evans, Michael D.;Roberg, Kathy A.;Anderson, Elizabeth L.;Burton, Ryan M.;Salazar, Lisa P.;DaSilva, Douglas F.;Shanovich, Kathleen M.;Tisler, Christopher J.;Gern, James E.;Lemanske, Robert F., Jr.
通讯作者：
Lemanske, Robert F., Jr.
DOI：
10.1016/j.jaci.2008.10.007
发表时间：
2009-01
期刊：
The Journal of allergy and clinical immunology
影响因子：
--
作者：
Miller EK;Edwards KM;Weinberg GA;Iwane MK;Griffin MR;Hall CB;Zhu Y;Szilagyi PG;Morin LL;Heil LH;Lu X;Williams JV;New Vaccine Surveillance Network
通讯作者：
New Vaccine Surveillance Network
DOI：
10.1164/ajrccm.159.3.9801052
发表时间：
1999-03-01
影响因子：
24.7
作者：
Rakes, CP;Arruda, E;Heymann, PW
通讯作者：
Heymann, PW
影响因子：
11.8
作者：
Khetsuriani N;Lu X;Teague WG;Kazerouni N;Anderson LJ;Erdman DD
通讯作者：
Erdman DD