Prevalence and Characterization of Thyroid Hemiagenesis in Japan: The Fukushima Health Management Survey.
Prevalence and Characterization of Thyroid Hemiagenesis in Japan: The Fukushima Health Management Survey.
复制标题
日本甲状腺血生成的患病率和特征：福岛健康管理调查。
DOI：
10.1089/thy.2016.0662
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发表时间：
2017-08
期刊：
影响因子：
--
通讯作者：
Yamashita S
中科院分区：
文献类型：
--
作者：
Suzuki S;Midorikawa S;Matsuzuka T;Fukushima T;Ito Y;Shimura H;Takahashi H;Ohira T;Ohtsuru A;Abe M;Suzuki S;Yamashita S
背景：甲状腺功能不全是一种罕见的先天性变异，其特征是一个甲状腺叶缺乏发育，没有临床表现。方法：本研究旨在确定日本正常人群中甲状腺功能不全的患病率和特征。本横断面研究于2011年10月9日至2015年4月30日进行。在福岛健康管理调查中，总共对299,908名儿童和年轻人进行了检查，以确定是否存在甲状腺发育不全或甲状腺功能不全。测量了其中292,452名受试者的甲状腺宽度、厚度和长度。结果：甲状腺发育不全13例，甲状腺功能不全67例（0.02%，22.3/10万人）。虽然性别差异不显著（p = 0.067），但男女比例为1.67:1.00。女性在右侧偏孕中占明显优势，而男性和女性在左侧偏孕中没有差异。在年龄和体表面积的第2.5和97.5百分位数处测定每个性别的甲状腺体积。多因素回归分析显示，甲状腺体积大与对侧偏瘫存在独立相关（p < 0.001）。结论：本研究中甲状腺功能减退的发生率与国外报道的情况一致。女性右侧半胱氨酸的发生率较高，有半胱氨酸的患者对侧脑叶较大，这可能是由于代偿反馈机制防止甲状腺功能减退所致。此外，与异位甲状腺患者的情况类似，发生偏血，尤其是右侧偏血可能受到与性别有关的因素的影响。
Background: Thyroid hemiagenesis is a rare congenital variant characterized by the lack of development of one thyroid lobe with no clinical manifestations. Methods: This study was performed to determine the prevalence and characteristics of thyroid hemiagenesis in a normal Japanese population. This cross-sectional study was performed from October 9, 2011, to April 30, 2015. In total, 299,908 children and young adults in the Fukushima Health Management Survey were examined to determine the presence of thyroid agenesis or hemiagenesis. Thyroid width, thickness, and length were measured in 292,452 of these subjects. Results: Thyroid agenesis was diagnosed in 13 subjects, and hemiagenesis was detected in 67 subjects (0.02%; 22.3/100,000 individuals). Although there was no significant sex-related difference (p = 0.067), the female:male ratio was 1.67:1.00. Females were significantly dominant in right hemiagenesis, while there was no difference in left hemiagenesis between males and females. The thyroid volumes at the 2.5th and 97.5th percentiles for age and body surface area were determined for each sex. Multivariate regression analysis showed that a large hemithyroid volume was independently associated with the presence of contralateral hemiagenesis (p < 0.001). Conclusion: The prevalence of thyroid hemiagenesis in the present study is in agreement with that reported in other countries. The prevalence of right hemiagenesis was higher in females, and the larger contralateral lobe in patients with rather than without hemiagenesis may have been caused by a compensatory feedback mechanism to prevent hypothyroidism. In addition, the prevalence of hemiagenesis, especially right hemiagenesis, may be affected by sex-related factors similar to those in patients with an ectopic thyroid gland.
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影响因子：
--
作者：
Du Bois, D;Du Bois, EF
通讯作者：
Du Bois, EF
影响因子：
8.8
作者：
Jacob, P;Kenigsberg, Y;Paretzke, HG
通讯作者：
Paretzke, HG
影响因子：
3.7
作者：
Hayashida N;Imaizumi M;Shimura H;Okubo N;Asari Y;Nigawara T;Midorikawa S;Kotani K;Nakaji S;Otsuru A;Akamizu T;Kitaoka M;Suzuki S;Taniguchi N;Yamashita S;Takamura N;Investigation Committee for the Proportion of Thyroid Ultrasound Findings
通讯作者：
Investigation Committee for the Proportion of Thyroid Ultrasound Findings
影响因子：
6.6
作者：
Mikosch, P;Gallowitsch, HJ;Lind, P
通讯作者：
Lind, P
影响因子：
5.8
作者：
Devos, H;Rodd, C;Van Vliet, G
通讯作者：
Van Vliet, G