Female rats exposed to stress and alcohol show impaired memory and increased depressive-like behaviors.
Female rats exposed to stress and alcohol show impaired memory and increased depressive-like behaviors.
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DOI：
10.1016/j.physbeh.2013.09.009
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发表时间：
2014-01-17
影响因子：
2.9
通讯作者：
Luine VN
中科院分区：
文献类型：
--
作者：
Gomez JL;Luine VN
暴露于日常生活压力源与焦虑，抑郁和整体负面影响的增加有关。酒精或其他精神药物通常用于缓解压力。虽然女性患情绪障碍的可能性是男性的两倍多，而且更容易产生依赖性，但她们很少接受检查。在这项研究中，雌性大鼠接受无应激/无酒精对照（CON）、单独酒精（ALC）、单独应激（STR）或应激加酒精（STR+ALC）。应激包括6小时/天/7天的束缚，束缚后立即通过胃管饲法以2.0 g/kg的剂量给予酒精。依赖性测量包括利用物体识别（OR）、Y-迷宫、高架十字迷宫（ESTA）、强迫游泳（FST）、血液酒精含量、皮质酮水平和体重的测试。ALC，STR+ALC，但不是单独的压力，受损的记忆或。所有处理均损害Y-迷宫上的空间记忆。焦虑不受影响，但用酒精或结合压力治疗的大鼠在FST上表现出增加的不动性，这表明酒精诱导的抑郁症。以前，我们发现酒精可以逆转压力对男性记忆和情绪的有害影响，但目前的结果显示，当两种治疗结合时，女性的反应是负面的。因此，对酒精、压力及其组合的反应表明，需要针对性治疗来应对压力引起的行为变化，并且用酒精自我治疗来科普压力可能对女性有害。
Exposure to daily life stressors is associated with increases in anxiety, depression, and overall negative affect. Alcohol or other psychoactive drugs are often used to alleviate stress effects. While females are more than twice as likely to develop mood disorders and are more susceptible to dependency than males, they are infrequently examined. In this study, female rats received no stress/no alcohol control (CON), alcohol alone (ALC), stress alone (STR), or stress plus alcohol (STR+ALC). Stress consisted of restraint for 6hr/day/7days, and alcohol was administered immediately following restraint via gastric gavage at a dose of 2.0 g/kg. Dependent measures included tests utilizing object recognition (OR), Y-maze, elevated plus maze (EPM), forced swim (FST), blood alcohol content, corticosterone levels, and body weights. ALC, STR+ALC, but not stress alone, impaired memory on OR. All treatments impaired spatial memory on the Y-maze. Anxiety was not affected on the EPM, but rats treated with alcohol or in combination with stress showed increased immobility on the FST, suggestive of alcohol-induced depression. Previously, we found alcohol reversed deleterious effects of stress on memory and mood in males, but current results show females reacted negatively when the two treatments were combined. Thus, responses to alcohol, stress and their combination suggest that sex specific treatments are needed for stress-induced behavioral changes and that self-medicating with alcohol to cope with stress maybe deleterious in females.
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影响因子：
2.3
作者：
Gomez, Juan L.;Lewis, Michael J.;Luine, Victoria N.
通讯作者：
Luine, Victoria N.
影响因子：
4.2
作者：
Hernandez-Avila, CA;Rounsaville, BJ;Kranzler, HR
通讯作者：
Kranzler, HR
影响因子：
7.6
作者：
Breese, GR;Knapp, DJ;Overstreet, DH
通讯作者：
Overstreet, DH
影响因子：
1.9
作者：
Conrad CD;McLaughlin KJ;Huynh TN;El-Ashmawy M;Sparks M
通讯作者：
Sparks M
DOI：
10.1111/j.1530-0277.2009.01027.x
发表时间：
2009-11-01
影响因子：
3.2
作者：
Griffin, William C., III;Lopez, Marcelo F.;Becker, Howard C.
通讯作者：
Becker, Howard C.