Hydrogels as promising carriers for the delivery of food bioactive ingredients.
Hydrogels as promising carriers for the delivery of food bioactive ingredients.
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水凝胶作为食品生物活性成分输送的有前途的载体
DOI：
10.3389/fnut.2022.1006520
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发表时间：
2022
影响因子：
5
通讯作者：
Hu B
中科院分区：
文献类型：
--
作者：
Li M;He X;Zhao R;Shi Q;Nian Y;Hu B
与西方饮食和生活方式相关的公共卫生挑战的负担正在增加。营养保健品因其具有促进健康的作用而受到越来越多的关注。然而，在胃肠道（GI）中，营养品不仅受到胃的苛刻酸性环境和各种消化酶的影响，而且还受到肠胆汁盐的抗菌活性和肠道微生物群蛋白酶的作用。不幸的是，到达胃肠道部位吸收或发挥生物活性的营养品的量总是有限的，这对口服食用期间一定高含量的营养品的保护提出了很高的要求。水凝胶是由聚合物链交联形成的三维聚合物多孔网络，其可以容纳大量的水。与纳米颗粒、微胶囊等微观尺度的载体相比，水凝胶具有宏观体积性质、可调粘弹性和大空间结构等特点，更适合作为食品中的药物载体。关于在食品中的应用，天然聚合物基水凝胶通常是安全和受欢迎的，因为它们的来源具有可负担性、生物降解性和生物相容性的吸引人的特性。虽然化学交联在水凝胶的制备中得到了广泛的应用，但在食品领域的研究中，更倾向于物理交联。合理设计天然高分子水凝胶的结构是寻找合适的功能性载体的关键，可以提高天然高分子水凝胶的粘附性、酸稳定性、耐胆盐性和控释性能。讨论了以蛋白质、多糖或它们的混合物为载体制备的水凝胶对功能性成分，主要是酚类成分、维生素、益生菌的释放，以期为水凝胶在释放系统中的广泛应用提供启示。通过食品聚合物和小分子成分之间的相互作用在胃肠道中原位形成水凝胶，提高水凝胶中营养保健品的负载量，开发胃粘附性水凝胶以及水凝胶对肠道微生物群的靶向修饰可能是进一步的努力。
The burden of public health challenges associated with the western dietary and living style is growing. Nutraceuticals have been paid increasing attentions due to their effects in promotion of health. However, in the gastrointestinal (GI) tract, the nutraceuticals suffer from not only the harsh acidic environment of the stomach and a variety of digestive enzymes, but also the antibacterial activity of intestinal bile salts and the action of protease from the gut microbiota. The amount of the nutraceuticals arriving at the sites in GI tract for absorption or exerting the bioactivities is always unfortunately limited, which puts forward high requirements for protection of nutraceuticals in a certain high contents during oral consumption. Hydrogels are three-dimensional polymeric porous networks formed by the cross-linking of polymer chains, which can hold huge amounts of water. Compared with other carries with the size in microscopic scale such as nanoparticle and microcapsules, hydrogels could be considered to be more suitable delivery systems in food due to their macroscopic bulk properties, adjustable viscoelasticity and large spatial structure for embedding nutraceuticals. Regarding to the applications in food, natural polymer-based hydrogels are commonly safe and popular due to their source with the appealing characteristics of affordability, biodegradability and biocompatibility. Although chemical crosslinking has been widely utilized in preparation of hydrogels, it prefers the physical crosslinking in the researches in food. The reasonable design for the structure of natural polymeric hydrogels is essential for seeking the favorable functionalities to apply in the delivery system, and it could be possible to obtain the enhanced adhesive property, acid stability, resistant to bile salt, and the controlled release behavior. The hydrogels prepared with proteins, polysaccharides or the mix of them to deliver the functional ingredients, mainly the phenolic components, vitamins, probiotics are discussed to obtain inspiration for the wide applications in delivery systems. Further efforts might be made in the in situ formation of hydrogels in GI tract through the interaction among food polymers and small-molecular ingredients, elevation of the loading contents of nutraceuticals in hydrogels, development of stomach adhesive hydrogels as well as targeting modification of gut microbiota by the hydrogels.
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影响因子：
1
作者：
Das, Subhraseema;Subuddhi, Usharani
通讯作者：
Subuddhi, Usharani
影响因子：
8.8
作者：
Chen, Hao;Gan, Jing;Yin, Lijun
通讯作者：
Yin, Lijun
影响因子：
2.9
作者：
Ajji, Z.;Mirjaliji, G.;Dada, H.
通讯作者：
Dada, H.
DOI：
10.1590/s0104-14282009000400006
发表时间：
2009-01-01
期刊：
Polímeros
影响因子：
--
作者：
Botaro, Vagner R.;Santos, Cláudio G.;Oliveira, Victor A.
通讯作者：
Oliveira, Victor A.
影响因子：
6
作者：
Croisier, Florence;Jerome, Christine
通讯作者：
Jerome, Christine