Comparison of Formulas for Calculating Low-density Lipoprotein Cholesterol in General Population and High-risk Patients with Cardiovascular Disease.
Comparison of Formulas for Calculating Low-density Lipoprotein Cholesterol in General Population and High-risk Patients with Cardiovascular Disease.
复制标题
DOI：
10.4070/kcj.2016.46.5.688
复制
发表时间：
2016-09
影响因子：
2.9
通讯作者：
Kim HC
中科院分区：
文献类型：
--
作者：
Choi H;Shim JS;Lee MH;Yoon YM;Choi DP;Kim HC
低密度脂蛋白胆固醇（LDL-C）是一种确定的心血管风险因素，通常可以通过计算总胆固醇、高密度脂蛋白胆固醇和甘油三酯浓度来确定。本研究的目的是在韩国人群中比较基于社区的组和基于医院的组中使用各种公式的LDL-C估计值与直接测量的LDL-C。共1498名参与者根据甘油三酯浓度分为四组：<100、100-199、200-299和≥300 mg/dL。使用弗里德瓦尔德、Chen、Vujovic、Hattori、de Cordova和Anandaraja公式计算LDL-C，并使用均相酶法直接测量。Pearson相关系数、组内相关系数（ICC）、Passing & Bablok回归和Bland-Altman图用于评估六种公式的性能。在所有甘油三酯范围中，弗里德瓦尔德公式的准确度最高（ICC=0.977; 95%置信区间0.974-0.979），而Vujovic公式在甘油三酯≥300 mg/dL的人群中的准确度最高（ICC=0.876; 98.75%置信区间0.668-0.951）。弗里德瓦尔德公式的平均差异最低（0.5 mg/dL），Vujovic公式的百分比误差最低（30.2%）。然而，LDL-C公式的低估随着甘油三酯浓度的增加而增加。LDL-C公式的准确度随甘油三酯浓度的差异而显著变化。相对于直接测量，弗里德瓦尔德公式在估计LDL-C方面优于其他公式，Vujovic公式适用于高脂血症样本;当无法直接测量时，可将其用作测量LDL-C的替代成本效益工具。
Low-density lipoprotein cholesterol (LDL-C), an established cardiovascular risk factor, can be generally determined by calculation from total cholesterol, high-density lipoprotein cholesterol, and triglyceride concentrations. The aim of this study was to compare LDL-C estimations using various formulas with directly measured LDL-C in a community-based group and hospital-based group among the Korean population. A total of 1498 participants were classified into four groups according to triglyceride concentrations as follows: <100, 100–199, 200–299, and ≥300 mg/dL. LDL-C was calculated using the Friedewald, Chen, Vujovic, Hattori, de Cordova, and Anandaraja formulas and directly measured using a homogenous enzymatic method. Pearson's correlation coefficients, intraclass correlation coefficients (ICC), Passing & Bablok regression, and Bland-Altman plots were used to evaluate the performance of six formulas. The Friedewald formula had the highest accuracy (ICC=0.977; 95% confidence interval 0.974-0.979) of all the triglyceride ranges, while the Vujovic formula had the highest accuracy (ICC=0.876; 98.75% confidence interval 0.668–0.951) in people with triglycerides ≥300 mg/dL. The mean difference was the lowest for the Friedewald formula (0.5 mg/dL) and the percentage error was the lowest for the Vujovic formula (30.2%). However, underestimation of the LDL-C formulas increased with triglyceride concentrations. The accuracy of the LDL-C formulas varied considerably with differences in triglyceride concentrations. The Friedewald formula outperformed other formulas for estimating LDL-C against a direct measurement and the Vujovic formula was suitable for hypertriglyceridemic samples; it could be used as an alternative cost-effective tool to measure LDL-C when the direct measurement cannot be afforded.
登录
查看更多内容
用于估计韩国成年人血清低密度脂蛋白胆固醇浓度的甘油三酯值的最佳范围：韩国国家健康和营养检查调查，2009 年。
影响因子：
4.5
作者：
Hwang YC;Ahn HY;Jeong IK;Ahn KJ;Chung HY
通讯作者：
Chung HY
影响因子：
2.2
作者：
Hanneman, Sandra K.
通讯作者：
Hanneman, Sandra K.
影响因子：
5
作者：
Tanno, Kozo;Okamura, Tomonori;Okayama, Akira
通讯作者：
Okayama, Akira
影响因子：
4.4
作者：
Choi, Su-Yeon;Park, Hyo Eun;Oh, Byung-Hee
通讯作者：
Oh, Byung-Hee
影响因子：
3.5
作者：
Anandaraja, S;Narang, R;Talwar, KK
通讯作者：
Talwar, KK