Optimal range of triglyceride values to estimate serum low density lipoprotein cholesterol concentration in Korean adults: the Korea National Health and Nutrition Examination Survey, 2009.
Optimal range of triglyceride values to estimate serum low density lipoprotein cholesterol concentration in Korean adults: the Korea National Health and Nutrition Examination Survey, 2009.
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用于估计韩国成年人血清低密度脂蛋白胆固醇浓度的甘油三酯值的最佳范围：韩国国家健康和营养检查调查，2009 年。
DOI：
10.3346/jkms.2012.27.12.1530
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发表时间：
2012-12
影响因子：
4.5
通讯作者：
Chung HY
中科院分区：
文献类型：
--
作者：
Hwang YC;Ahn HY;Jeong IK;Ahn KJ;Chung HY
本研究的目的是调查弗里德瓦尔德的公式的有效性，并提出一个范围内的甘油三酯值的公式可以使用没有显着的错误。这是一项使用2009年韩国国家健康和营养检查调查数据对1，929名20岁及以上受试者（946名男性和983名女性）进行的横断面分析。估计总人数为10 633 655人（男性5 846 384人，女性4 787 271人）。计算的和直接测量的低密度脂蛋白胆固醇（LDL-C）值高度相关（r = 0.96）;然而，在直接测量的和计算的LDL-C浓度之间观察到显著差异。低估组（10.5%）的受试者比高估组（11.4%）有更高的代谢异常。尽管血清甘油三酯水平显示与计算的和直接测量的LDL-C浓度之间的差异具有最大的独立相关性，但当甘油三酯浓度在36和298 mg/dL（93.2%）之间时，未观察到统计学显著性差异。总之，弗里德瓦尔德公式可准确估计韩国成人中直接测量的血清LDL-C浓度。然而，该公式可应用于血清甘油三酯浓度为36 - 298 mg/dL的受试者，无显著误差。
The aims of this study were to investigate the validity of Friedewald's formula and to propose a range of triglyceride values over which the formula can be used without significant error. This was a cross-sectional analysis of 1,929 subjects (946 males and 983 females) aged 20 yr and older using data of the Korea National Health and Nutrition Examination Survey in 2009. Estimated total number was considered to be 10,633,655 (5,846,384 males and 4,787,271 females). Calculated and directly-measured low density lipoprotein cholesterol (LDL-C) values were highly correlated (r = 0.96); however, significant differences were observed between the directly-measured and calculated LDL-C concentrations. Subjects in the underestimated group (10.5%) had higher dysmetabolic profiles than those in the overestimated group (11.4%). Although serum triglyceride level showed the greatest independent association with differences between the calculated and directly-measured LDL-C concentrations, no statistically significant differences were noted when triglyceride concentration was between 36 and 298 mg/dL (93.2%). In conclusion, Friedewald's formula accurately estimates directly-measured serum LDL-C concentration in Korean adults. However, the formula can be applied to subjects with serum triglyceride concentrations from 36 to 298 mg/dL without significant error.
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