"Resting" CBF in the epileptic baboon: correlation with ketamine dose and interictal epileptic discharges.
"Resting" CBF in the epileptic baboon: correlation with ketamine dose and interictal epileptic discharges.
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DOI：
10.1016/j.eplepsyres.2008.07.015
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发表时间：
2008-11
影响因子：
2.2
通讯作者：
Williams, Jeff T.
中科院分区：
文献类型：
--
作者：
Szabo, C. Akos;Narayana, Shalini;Franklin, Crystal;Knape, Koyle D.;Davis, M. Duff;Fox, Peter T.;Leland, M. Michelle;Williams, Jeff T.
光敏癫痫（SZ）狒狒在间歇性光刺激（ILS）期间表现出与无症状对照（CTL）不同的脑血流（CBF）激活模式。本研究比较了 PS 和 CTL 动物之间的“静息”CBF，以及 PS 和 CTL 动物之间 CBF 与氯胺酮剂量和发作间期癫痫放电 (IED) 的相关性。对 8 只 PS 狒狒和 8 只 CTL 狒狒（性别和体重匹配）进行连续静脉注射氯胺酮，并维持亚麻醉剂量（4.8-14.6 毫克/公斤/小时）。对每只动物尝试进行三项静息 H215O-PET 研究（CTI/西门子 HR+ 扫描仪）。图像以 3D 模式采集（63 个连续切片，2.4 毫米厚度）。 PET 图像与 MRI 图像共同配准（3T Siemens Trio，T1 加权 3D Turboflash 序列，TE/TR/TI = 3.04/2100/785 毫秒，翻转角 = 13 度）。脑电图用于监测镇静深度和量化简易爆炸装置发生率。比较 PS 组和 CTL 组之间的区域 CBF，并分析氯胺酮剂量和简易爆炸装置发生率的相关性。当对接受相似剂量氯胺酮的任一组的动物子集进行比较时，PS动物表现出枕叶的相对CBF增加和额叶的相对CBF减少。与氯胺酮剂量的相关性分析证实了 PS 动物的额叶和枕叶变化。 CBF 与氯胺酮剂量和 IED 发生率的负相关在正面重叠。虽然额叶 CBF 也与 IED 率呈负相关，但顶叶呈正相关。 PS 和 CTL 狒狒的“休息”CBF 不同。 CBF与氯胺酮剂量的相关性分析表明，PS动物枕叶CBF增加，额叶受氯胺酮驱动。虽然额叶 CBF 降低可能与氯胺酮激活 IED 的倾向有关，但 CBF 与 IED 发生率的正相关表明顶叶参与了 IED 的生成。
Photosensitive epileptic (SZ) baboons demonstrate different cerebral blood flow (CBF) activation patterns from asymptomatic controls (CTL) during intermittent light stimulation (ILS). This study compares “resting” CBF between PS and CTL animals, and CBF correlations with ketamine dose and interictal epileptic discharges (IEDs) between PS and CTL animals. Continuous intravenous ketamine was administered to eight PS and eight CTL baboons (matched for gender and weight), and maintained at subanesthetic doses (4.8–14.6 mg/kg/hr). Three resting H215O-PET studies were attempted in each animal (CTI/Siemens HR+ scanner). Images were acquired in 3D mode (63 contiguous slices, 2.4 mm thickness). PET images were co-registered with MRI images (3T Siemens Trio, T1-weighted 3D Turboflash sequence, TE/TR/TI = 3.04/2100/785 msec, flip angle=13 degrees). EEG was used to monitor depth of sedation and for quantification of IED rates. Regional CBF was compared between PS and CTL groups and correlations were analyzed for ketamine dose and IED rates. When subsets of animals of either group, receiving similar doses of ketamine were compared, PS animals demonstrated relative CBF increases in the occipital lobes and decreases in the frontal lobes. Correlation analyses with ketamine dose confirmed the frontal and occipital lobe changes in the PS animals. The negative correlations of CBF with ketamine dose and IED rate overlapped frontally. While frontal lobe CBF was also negatively correlated with IED rate, positive correlations were found in the parietal lobe. “Resting” CBF differs between PS and CTL baboons. Correlation analyses of CBF and ketamine dose reveal that occipital lobe CBF increases and frontal lobe in PS animals are driven by ketamine. While frontal lobe CBF decreases may be related to ketamine’s propensity to activate IEDs, positive CBF correlations with IED rate suggest involvement of the parietal lobes in their generation.
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影响因子：
9.9
作者：
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通讯作者：
BAMFORTH, BJ
影响因子：
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作者：
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通讯作者：
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