Glycated albumin and direct low density lipoprotein cholesterol levels in type 2 diabetes mellitus.
Glycated albumin and direct low density lipoprotein cholesterol levels in type 2 diabetes mellitus.
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DOI：
10.1016/j.cca.2009.05.015
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发表时间：
2009-08
期刊：
影响因子：
--
通讯作者：
Nathan DM
中科院分区：
文献类型：
--
作者：
Ai M;Otokozawa S;Schaefer EJ;Asztalos BF;Nakajima K;Shrader P;Kathiresan S;Meigs JB;Williams G;Nathan DM
糖尿病是冠心病(CHD)、肾功能衰竭、视网膜病变和神经病变的主要危险因素。降低糖化血红蛋白(HbA1c)和低密度脂蛋白胆固醇(LDL-C)与降低这些并发症的风险有关。我们评估了糖化白蛋白(GA)和直接低密度脂蛋白(LDL-C)这两种新的分析方法在评估不同人群和2型糖尿病患者特定亚组中糖尿病控制和血脂方面的有效性，并与HbA1c和计算的LDL-C进行了比较。我们采集了616名2型糖尿病男性和女性患者和895名非糖尿病对照组的多民族人群的空腹血样，并测定了HbA1c、GA和直接低密度脂蛋白-C以及其他参数。用来测量不同时期血糖的糖化血红蛋白和糖化血红蛋白水平的相关性为r=0.7(p<；0.001)，男性患者的平均值分别比对照组高38.7%和43.4%，女性患者的平均值分别比对照组高41.1%和40.1%(p<；0.001)。低密度脂蛋白胆固醇计算值与直接值高度相关(r=0.96p<；0.001)。在由性别、种族、年龄和其他因素定义的亚组中，HbA1c和GA以及计算的和直接的LDL-C之间的相关性相似。在大多数受试者中，与直接测量相比，计算的低密度脂蛋白胆固醇提供了对空腹低密度脂蛋白胆固醇的准确评估，但高甘油三酯血症除外，在糖尿病和非糖尿病受试者中，GA与HbA1c相关，并可作为短期糖尿病控制的合理标记物。
Diabetes mellitus is a major risk factor for coronary heart disease (CHD), renal failure, retinopathy, and neuropathy. Lowering glycosylated hemoglobin (HbA1c) as well as low-density lipoprotein-cholesterol (LDL-C) has been associated with a decreased risk of these complications. We evaluated the utility of glycated albumin (GA) and direct LDL-C, 2 novel assays, as compared to HbA1c and calculated LDL-C, in evaluating diabetes control and lipid in a heterogeneous population and in specific subgroups of patients with type 2 diabetes mellitus. We obtained fasting blood samples and measured HbA1c, GA, and direct LDL-C, as well as other parameters, in a multi-ethnic population of 616 male and female patients with type 2 diabetes and 895 non-diabetic controls. HbA1c and GA levels, which measure different periods of glycemia, had a correlation of r=0.70 (p<0.001), and mean values in patients were 38.7% and 43.4% higher, respectively, than controls in men, and 41.1% and 40.1% higher, respectively, than controls, in women (both p<0.001). Calculated and direct LDL-C values correlated very highly (r=0.96, p<0.001). The correlations between HbA1c and GA, and between calculated and direct LDL-C were similar for subgroups defined by gender, race, age, and other factors. Calculated LDL-C provides an accurate assessment of fasting LDL-C compared with a direct measurement in most subjects, except for those with hypertriglyceridemia, and GA correlates with HbA1c in diabetic and non-diabetic subjects and may serve as a reasonable marker of short term diabetic control.
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影响因子：
16.2
作者：
Schaefer, EJ;McNamara, JR;Wilson, PWF
通讯作者：
Wilson, PWF
影响因子：
13.6
作者：
Inaba, Masaaki;Okuno, Senji;Nishizawa, Yoshiki
通讯作者：
Nishizawa, Yoshiki
影响因子：
0.7
作者：
Chujo, Keiko;Shima, Kenji;Kawashima, Syu
通讯作者：
Kawashima, Syu
影响因子：
2.8
作者：
Schaefer, EJ;Audelin, MC;Rubenstein, JJ
通讯作者：
Rubenstein, JJ
影响因子：
5.1
作者：
OHKUBO, Y;KISHIKAWA, H;SHICHIRI, M
通讯作者：
SHICHIRI, M