Trends in human birth weight across two successive generations.
Trends in human birth weight across two successive generations.
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DOI：
10.1007/s12098-008-0066-x
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发表时间：
2008-02
影响因子：
4.3
通讯作者：
Raghupathy, P.
中科院分区：
文献类型：
--
作者：
Agnihotri, B.;Antonisamy, B.;Priya, G.;Fall, C. H. D.;Raghupathy, P.
在印度这样的发展中国家，确定父母和子女出生体重（BW）之间的相关性。这项研究涉及两个连续几代的出生队列。父母队列包括来自早期研究的472名父亲和422名母亲。他们在出生和成年时的人体测量细节是可用的。他们所生的1525个孩子组成了后代队列。从后代队列的医院记录中获得BW。计算比值比和回归系数，以估计低出生体重（LBW）父母产生LBW婴儿的风险，并在调整混杂因素后量化影响。LBW母亲分娩LBW婴儿的风险为2.8倍（95%CI 1.2 - 6.4）（p=0.02），LBW父亲分娩LBW婴儿的风险为2倍（OR 2.2; 95%CI 1.0 - 4.8; p=0.05）。母亲体重每增加100 g，后代体重增加14 g;父亲体重的相应数字为18.1 g（两者p<0.001）。两代之间，LBW的发生率从19.7%下降到17.2%（p=0.1）。雄性动物的平均BW增加（2846 g vs 2861 g; p=0.59），但雌性动物的平均BW未增加（2790 g vs 2743 g; p=0.08）。母亲和父亲的体重都是后代体重的强有力的决定因素。母亲的体重对后代体重的影响比发达国家要弱。印度妇女在子宫内生长受限的发生率较高，因此表现出更强的宫内限制可能是原因之一。父系效应可能受子代遗传的父系基因控制。
To determine the correlation between parental and offspring birthweight (BW) in a developing country like India. The study involved two birth cohorts of successive generations. The parental cohort comprised of 472 fathers and 422 mothers from an earlier study. Details of their anthropometry at birth and in adulthood were available. 1525 children born to them comprised the offspring cohort. BW was obtained from hospital records for the offspring cohort. Odds ratios and regression coefficients were calculated to estimate the risks of a low birth weight (LBW) parent producing a LBW baby and quantitate the effects after adjusting for confounders. A LBW mother had a 2.8 times risk (95%CI 1.2 - 6.4) of delivering a LBW baby (p=0.02) and a LBW father was twice as likely to produce a LBW baby (OR 2.2; 95%CI 1.0 - 4.8; p=0.05). Every 100g increase in maternal BW was associated with an increase in offspring BW of 14g; the equivalent figure for paternal BW was 18.1g (p<0.001 for both). Between the generations, the incidence of LBW decreased from 19.7% to 17.2% (p=0.1). Mean BW increased in males (2846 g v 2861 g; p=0.59) but not in females (2790 g v 2743 g; p=0.08). Both maternal and paternal BW are strong determinants of offspring BW. The effect of mothers’ BW on offspring BW is weaker than that seen in developed nations. Stronger intrauterine constraint exhibited by Indian women secondary to a higher prevalence of growth restriction in utero may be responsible. Paternal effects may be governed by paternal genes inherited by the offspring.
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影响因子：
30.8
作者：
Dunger, DB;Ong, KKL;Todd, JA
通讯作者：
Todd, JA
影响因子：
2.8
作者：
SANDERSON, M;EMANUEL, I;HOLT, VL
通讯作者：
HOLT, VL
影响因子：
1.7
作者：
OUNSTED, M;SCOTT, A;OUNSTED, C
通讯作者：
OUNSTED, C
DOI：
10.1111/j.1471-0528.1992.tb14396.x
发表时间：
1992-01-01
期刊：
BRITISH JOURNAL OF OBSTETRICS AND GYNAECOLOGY
影响因子：
--
作者：
EMANUEL, I;FILAKTI, H;EVANS, SJW
通讯作者：
EVANS, SJW
影响因子：
120.7
作者：
HACKMAN, E;EMANUEL, I;DALING, J
通讯作者：
DALING, J