Cerebral oxygen metabolism from MRI susceptibility.
Cerebral oxygen metabolism from MRI susceptibility.
复制标题
MRI易感性的脑氧代谢。
DOI：
10.1016/j.neuroimage.2023.120189
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发表时间：
2023-08-01
期刊：
影响因子：
5.7
通讯作者：
Lee H
中科院分区：
文献类型：
--
作者：
Biondetti E;Cho J;Lee H
本文概述了利用血液磁化率特性评估脑氧代谢的MRI方法，包括组织氧提取分数（OEF）和脑氧代谢率（）。第一部分主要描述血液磁化率及其对MRI信号的影响。在脉管系统中循环的血液可以具有抗磁性（含氧血红蛋白）或顺磁性（含脱氧血红蛋白）。氧合血红蛋白和脱氧血红蛋白之间的总体平衡决定了感应磁场，进而通过额外的相位积累调节MRI信号的横向弛豫衰减。本综述的以下部分说明了用于量化OEF和OEF的基于敏感性的技术的基本原则。这里详细介绍了这些技术是提供OEF的全局（OxFlow）还是局部（定量敏感性映射- QSM，校准，定量）测量，以及它们考虑的信号成分（幅度或相位）和组织池（血管内或血管外）。还描述了每种方法的验证研究和潜在局限性。后者包括（但不限于）实验设置中的挑战，信号建模的准确性以及对测量信号的假设。最后一节概述了这些技术在健康衰老和神经退行性疾病中的临床应用，并将这些报告与金标准PET的结果进行了对比。
This article provides an overview of MRI methods exploiting magnetic susceptibility properties of blood to assess cerebral oxygen metabolism, including the tissue oxygen extraction fraction (OEF) and the cerebral metabolic rate of oxygen (). The first section is devoted to describing blood magnetic susceptibility and its effect on the MRI signal. Blood circulating in the vasculature can have diamagnetic (oxyhemoglobin) or paramagnetic properties (deoxyhemoglobin). The overall balance between oxygenated and deoxygenated hemoglobin determines the induced magnetic field which, in turn, modulates the transverse relaxation decay of the MRI signal via additional phase accumulation. The following sections of this review then illustrate the principles underpinning susceptibility-based techniques for quantifying OEF and . Here, it is detailed whether these techniques provide global (OxFlow) or local (Quantitative Susceptibility Mapping - QSM, calibrated , quantitative , ) measurements of OEF or , and what signal components (magnitude or phase) and tissue pools they consider (intravascular or extravascular). Validations studies and potential limitations of each method are also described. The latter include (but are not limited to) challenges in the experimenta setup, the accuracy of signal modeling, and assumptions on the measured signal. The last section outlines the clinical uses of these techniques in healthy aging and neurodegenerative diseases and contextualizes these reports relative to results from gold-standard PET.
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