Macrophage migration inhibitory factor anti-thrombin III complexes are decreased in bladder cancer patient serum: Complex formation as a mechanism of inactivation.
Macrophage migration inhibitory factor anti-thrombin III complexes are decreased in bladder cancer patient serum: Complex formation as a mechanism of inactivation.
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DOI：
10.1016/j.canlet.2009.08.025
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发表时间：
2010-04-01
期刊：
影响因子：
9.7
通讯作者：
Vera, Pedro L.
中科院分区：
文献类型：
--
作者：
Meyer-Siegler, Katherine L.;Cox, Jacob;Leng, Lin;Bucala, Richard;Vera, Pedro L.
越来越多的证据表明，促炎细胞因子巨噬细胞迁移抑制因子（MIF）可能是慢性炎症和致癌作用之间的重要联系，各种癌症患者血清MIF的增加就证明了这一点。本研究确定抗凝血酶III（ATIII）作为一种内源性MIF结合蛋白，降低MIF的生物活性。与正常患者（n= 50）相比，膀胱癌患者（TCC II期，n= 50）的血清MIF增加，而膀胱癌患者血清中的ATIII-MIF复合物减少。这些数据表明，膀胱癌患者血清中存在增加的循环水平的生物活性MIF。
Mounting evidence suggests that the proinflammatory cytokine macrophage migration inhibitory factor (MIF) may serve as an important link between chronic inflammation and carcinogenesis as evidenced by the increase in serum MIF found in patients with various cancers. The present study identifies anti-thrombin III (ATIII) as an endogenous MIF binding protein, which reduces MIF biological activity. Serum MIF in bladder cancer patients (TCC stage II, n=50) was increased when compared to normal patients (n=50), while ATIII-MIF complexes were decreased in bladder cancer patient serum. These data suggest that increased circulating levels of bioactive MIF are present in bladder cancer patient serum.
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影响因子：
6.2
作者：
Brown, FG;Nikolic-Paterson, DJ;Atkins, RC
通讯作者：
Atkins, RC
影响因子：
82.9
作者：
Calandra, T;Echtenacher, B;Glauser, MP
通讯作者：
Glauser, MP
影响因子：
6.6
作者：
Meyer-Siegler, KL;Iczkowski, KA;Vera, PL
通讯作者：
Vera, PL
影响因子：
6.2
作者：
Meyer-Siegler, KL;Bellino, MA;Tannenbaum, M
通讯作者：
Tannenbaum, M
影响因子：
3.4
作者：
FRIGOLA, A;ANGELONI, S;CERQUETI, AR
通讯作者：
CERQUETI, AR