Associations between HLA class I alleles and the prevalence of nasopharyngeal carcinoma (NPC) among Tunisians.
Associations between HLA class I alleles and the prevalence of nasopharyngeal carcinoma (NPC) among Tunisians.
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突尼斯人中HLA I类等位基因与鼻咽癌（NPC）的患病率之间的关联。
DOI：
10.1186/1479-5876-5-22
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发表时间：
2007-05-04
影响因子：
7.4
通讯作者：
Marincola FM
中科院分区：
文献类型：
--
作者：
Li X;Ghandri N;Piancatelli D;Adams S;Chen D;Robbins FM;Wang E;Monaco A;Selleri S;Bouaouina N;Stroncek D;Adorno D;Chouchane L;Marincola FM
鼻咽癌(NPC)在南亚和地中海北非的高患病率表明遗传易感性等因素。虽然人类白细胞抗原(HLA)单倍型与亚洲人的鼻咽癌易感性有确凿的联系，但对北非马格里比亚人的研究还不够深入。然而，低分辨率的血清学方法发现与人类白细胞抗原B5、B13和B18呈弱阳性相关，与人类白细胞抗原B14呈阴性相关。采用基于序列的分型(SBT)方法，对136例性别、年龄和地理分布相匹配的突尼斯鼻咽癌患者和148例正常突尼斯人的HLAI类基因频率进行了直接比较。此外，还考虑了马格里比亚鼻咽癌的双峰年龄分布。我们还比较了正常突尼斯人和摩洛哥北部柏柏尔人(ME)的HL A频率，以评估本研究中的突尼斯人是否可以被视为其他马格里布人的代表。HL A-B14和-Cw08与鼻咽癌呈负相关(奇数比分别为0.09和0.18，Fisher p2值分别为0.0001和0.003)。此外，观察到了与人类白细胞抗原-B-18、-B51(-B5的分裂)和-B57(全部为0.025)的正相关，证实了先前在马格里布的发现。鼻咽癌患者的HLAB14/Cw*08单倍型频率(HF)为0.007，而突尼斯人(OR=0.12；p2值=0.001)和摩洛哥人为0.057。这项研究证实了先前通过血清学分型注意到的几个与人类白细胞抗原I类等位基因和马格里比亚人鼻咽癌患病率之间的关联。此外，我们确定了一种在突尼斯鼻咽癌患者中罕见的假定单倍型，该单倍型可能作为进一步易感性研究的遗传标记。
The high prevalence of nasopharyngeal cancer (NPC) in Southern Asia and Mediterranean Northern Africa suggests genetic predisposition among other factors. While Human Leukocyte Antigen (HLA) haplotypes have been conclusively associated with NPC predisposition in Asians, Northern African Maghrebians have been less intensely studied. However, low resolution serological methods identified weak positive associations with HLA-B5, B13 and B18 and a negative with HLA-B14. Using sequence based typing (SBT), we performed a direct comparison of HLA class I frequencies in a cohort of 136 Tunisian patients with NPC matched for gender, age and geographical residence to 148 normal Tunisians. The bimodal age distribution of NPC in Maghrebians was also taken into account. HLA frequencies in normal Tunisians were also compared with those of Northern Moroccan Berbers (ME) to evaluate whether the Tunisian population in this study could be considered representative of other Maghrebian populations. HLA-B14 and -Cw08 were negatively associated with NPC (odd ratio = 0.09 and 0.18 respectively, Fisher p2-value = 0.0001 and = 0.003). Moreover, positive associations were observed for HLA-B-18, -B51 (split of -B5) and -B57 (p2-value < 0.025 in all) confirming previous findings in Maghrebs. The HLA-B14/Cw*08 haplotype frequency (HF) was 0.007 in NPC patients compared to 0.057 in both Tunisian (OR = 0.12; p2-value = 0.001) and Moroccan controls. This study confirms several previous associations noted by serologic typing between HLA class I alleles and the prevalence of NPC in Maghrebians populations. In addition, we identified a putative haplotype rare in Tunisian patients with NPC that may serve as a genetic marker for further susceptibility studies.
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