Abnormal degree centrality in chronic users of codeine-containing cough syrups: A resting-state functional magnetic resonance imaging study.
Abnormal degree centrality in chronic users of codeine-containing cough syrups: A resting-state functional magnetic resonance imaging study.
复制标题
长期服用含可待因止咳糖浆的异常程度中心性：一项静息态功能磁共振成像研究。
DOI：
10.1016/j.nicl.2018.06.003
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发表时间：
2018
期刊：
影响因子：
--
通讯作者：
Jiang G
中科院分区：
文献类型：
--
作者：
Hua K;Wang T;Li C;Li S;Ma X;Li C;Li M;Fu S;Yin Y;Wu Y;Liu M;Yu K;Fang J;Wang P;Jiang G
含可待因的止咳糖浆（CCS）已成为全球年轻人中最常见的滥用药物之一。然而，CCS 依赖性的神经生物学机制尚不明确。因此，了解长期使用 CCS 的大脑异常对于制定有效的干预措施至关重要。本研究描述了长期使用 CCS 的人在体素水平上全脑功能网络的内在脱节模式。此外，程度中心性 (DC) 的变化与 Barratt 冲动量表 (BIS-11) 总分、剂量、CCS 使用持续时间以及首次使用止咳糖浆的年龄相关。目前的研究包括 38 名长期 CCS 用户和 34 名匹配的对照受试者。所有患者均使用 BIS-11 进行评估。接下来，从这些 CCS 用户和对照处获取静息态功能磁共振成像 (rs-fMRI) 数据集。使用图论方法分析全脑连接：度中心性（DC）。 CCS依赖个体在左侧顶下小叶和左侧颞中回表现出低DC值，而在右侧苍白球和右侧海马体中表现出高DC值（P<0.01，AlphaSim校正）。此外，左顶下小叶的平均 DC 值和注意力冲动评分以及首次使用 CCS 的年龄之间也存在显着相关性。 rs-fMRI 研究表明，全脑功能网络异常的内在脱节模式可能有助于深入了解 CCS 依赖个体的认知控制回路、奖励回路以及学习和记忆回路异常的神经基础。 CCS 的滥用在世界各地的年轻人中已经根深蒂固。 DC 是多个节点网络指标中更可靠、更引人注目的衡量标准之一。本研究描述了 CCS 依赖个体全脑功能网络的内在脱节模式。 CCS依赖个体的右侧苍白球、右侧海马体、左侧IPL和左侧颞中回的DC发生改变。左侧 IPL 的平均 DC 值和注意力冲动评分以及首次使用 CCS 的年龄之间建立了显着相关性。
Codeine-containing cough syrups (CCS) have become one of the most popular drugs of abuse in young population worldwide. However, the neurobiological mechanisms underlying CCS-dependence are yet ill-defined. Therefore, understanding the brain abnormalities in chronic users of CCS is crucial for developing effective interventions. The present study depicted the intrinsic dysconnectivity pattern of whole-brain functional networks at the voxel level in chronic users of CCS. In addition, the degree centrality (DC) changes were correlated to the Barratt Impulsiveness Scale (BIS-11) total score, dose, duration of CCS use, and the age at first use of cough syrups. The current study included 38 chronic CCS users and 34 matched control subjects. All patients were evaluated using the BIS-11. Next, resting-state functional magnetic resonance imaging (rs-fMRI) datasets were acquired from these CCS users and controls. Whole-brain connectivity was analyzed using a graph theory approach: degree centrality (DC). CCS-dependent individuals exhibited low DC values in the left inferior parietal lobule and the left middle temporal gyrus, while high DC values were noted in the right pallidum and the right hippocampus (P < 0.01, AlphaSim corrected). Also, significant correlations were established between average DC value in the left inferior parietal lobule and attentional impulsivity scores and the age at first CCS use. The rs-fMRI study suggested that the abnormal intrinsic dysconnectivity pattern of whole-brain functional networks may provide an insight into the neural substrates of abnormalities in the cognitive control circuit, the reward circuit, and the learning and memory circuit in CCS-dependent individuals. The abuse of CCS has gained a severe foothold among young individuals worldwide. DC is one of the more reliable and compelling measures among several nodal network metrics. The present study depicted intrinsic dysconnectivity pattern of whole-brain functional networks in CCS-dependent individuals. CCS-dependent individuals showed altered DC in the right pallidum, right hippocampus, left IPL and left middle temporal gyrus. Significant correlations were established between average DC value in the left IPL and attentional impulsivity scores and the age at first CCS use.
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影响因子：
5.3
作者：
Pruessner, JC;Champagne, F;Dagher, A
通讯作者：
Dagher, A
影响因子：
8.2
作者：
Jasinska, Agnes J.;Stein, Elliot A.;Kaiser, Jochen;Naumer, Marcus J.;Yalachkov, Yavor
通讯作者：
Yalachkov, Yavor
影响因子：
3.1
作者：
Plata-Bello, Julio;Modrono, Cristian;Luis Gonzales-Mora, Jose
通讯作者：
Luis Gonzales-Mora, Jose
影响因子：
3.4
作者：
Martins, Silvia S.;Keyes, Katherine M.;Grucza, Richard A.
通讯作者：
Grucza, Richard A.
影响因子：
7.6
作者：
Fotros, Aryandokht;Casey, Kevin F.;Leyton, Marco
通讯作者：
Leyton, Marco