Relevance of the NLRP3 Inflammasome in the Pathogenesis of Chronic Liver Disease.
Relevance of the NLRP3 Inflammasome in the Pathogenesis of Chronic Liver Disease.
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DOI：
10.3389/fimmu.2017.01728
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发表时间：
2017
影响因子：
7.3
通讯作者：
Li J
中科院分区：
文献类型：
--
作者：
Wu X;Dong L;Lin X;Li J
炎症是慢性肝病(CLD)的共同特征。炎症体是一种多蛋白复合体，能够感知和识别各种外源性和内源性危险信号，最终激活白介素1β和白介素18。炎症体系统的传感器组件是核苷酸结合的寡聚化结构域(NOD)样受体(NLRs)。含有3(NLRP3)结构域的NLRs家族的炎性小体参与了CLD的发生发展。然而，它引发肝脏炎症和损伤的分子机制尚不清楚。在这里，我们重点介绍NLRP3炎性小体激活在慢性肝病(包括病毒性肝炎、非酒精性脂肪性肝炎和酒精性肝病)进展中的潜在作用的最新进展，特别是它在动物模型中减轻肝脏炎症的能力。此外，我们还讨论了确定NLRP3炎症体信号级联作为治疗CLD的新靶点的各种药物抑制剂。综上所述，本文综述了NLRP3炎性小体在CLD的发生发展中的作用，并为临床治疗中抑制CLD的发展提供了重要靶点。
Inflammation is a common characteristic of chronic liver disease (CLD). Inflammasomes are multiprotein complexes that can sense and recognize various exogenous and endogenous danger signals, eventually activating interleukin (IL)-1β and IL-18. The sensor component of the inflammasome system is a nucleotide-binding oligomerization domain (NOD)-like receptors (NLRs). The NLRs family pyrin domain containing 3 (NLRP3) inflammasome has been involved in the initiation and progression of CLD. However, the molecular mechanisms by which it triggers liver inflammation and damage remain unclear. Here, we focus on recent advances on the potential role of NLRP3 inflammasome activation in the progression of CLD, including viral hepatitis, non-alcoholic steatohepatitis and alcoholic liver disease, and in particular, its ability to alleviate liver inflammation in animal models. Additionally, we also discuss various pharmacological inhibitors identifying the NLRP3 inflammasome signaling cascade as novel therapeutic targets in the treatment of CLD. In summary, this review summarizes the relevance of the NLRP3 inflammasome in the initiation and progression of CLD, and provides critical targets to suppress the development of CLD in clinical management.
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影响因子：
8.7
作者：
Elliott EI;Sutterwala FS
通讯作者：
Sutterwala FS
影响因子：
13.5
作者：
Csak, Timea;Ganz, Michal;Pespisa, Justin;Kodys, Karen;Dolganiuc, Angela;Szabo, Gyongyi
通讯作者：
Szabo, Gyongyi
影响因子：
7.2
作者：
de Zoete, Marcel R.;Palm, Noah W.;Flavell, Richard A.
通讯作者：
Flavell, Richard A.
影响因子：
7.3
作者：
de Zoete MR;Flavell RA
通讯作者：
Flavell RA
影响因子：
12.6
作者：
Chachay, Veronique S.;Macdonald, Graeme A.;Hickman, Ingrid J.
通讯作者：
Hickman, Ingrid J.