Polycystic ovary syndrome: an ancient disorder?

Polycystic ovary syndrome: an ancient disorder?
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DOI:
10.1016/j.fertnstert.2010.09.032
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发表时间:
2011-04
影响因子:
6.7
通讯作者:
Goodarzi, Mark O.
Goodarzi, Mark O.
中科院分区:
医学2区
文献类型:
--
作者:
Azziz, Ricardo;Dumesic, Daniel A.;Goodarzi, Mark O.

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多囊卵巢综合症似乎是一种古老的疾病,尽管生育能力下降,但它在人类进化中持续存在,因为它对受影响的女性有好处,例如更强壮、改善能量利用、为孩子和亲属提供抚养优势,以及降低围产期死亡风险。这增加了最终发现与PCOS相关的基因变异在种族和种族之间相似的可能性。
PCOS appears to be an ancient disorder, which persisted in human evolution despite reduced fecundity because of benefits to affected women such as greater sturdiness and improved energy utilization, a rearing advantage for their children and kin, and a reduction in the risk of perinatal mortality. This raises the possibility that gene variants eventually found to be associated with PCOS will be similar across ethnic groups and races.
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