The effect of obesity combined with low muscle strength on decline in mobility in older persons: results from the InCHIANTI study.
The effect of obesity combined with low muscle strength on decline in mobility in older persons: results from the InCHIANTI study.
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DOI：
10.1038/ijo.2009.62
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发表时间：
2009-06
影响因子：
4.9
通讯作者：
Ferrucci, L.
中科院分区：
文献类型：
--
作者：
Stenholm, S.;Alley, D.;Bandinelli, S.;Griswold, M. E.;Koskinen, S.;Rantanen, T.;Guralnik, J. M.;Ferrucci, L.
肥胖和肌肉损伤在老年人中日益普遍，对健康和身体机能产生不利影响。然而，并存的肥胖和肌肉损伤对身体功能下降的综合影响却研究得很少。我们研究了低肌肉力量的肥胖者是否比只有肥胖或低肌肉力量的人在步行速度和移动性方面经历了更大的下降。在基于人群的InCHIANTI研究中，对居住在基安蒂地理区域（托斯卡纳，意大利）的≥65岁社区居民成年人（n = 930）进行了6年随访。根据基线测量（1998 - 2000年），肥胖定义为体重指数（BMI）≥30 kg/m2，低肌肉力量定义为膝伸肌力量的最低性别特异性三分位数。在基线以及3年和6年随访时评估了行走速度和自我报告的活动能力残疾（行走400米或爬一段楼梯的能力）。在基线时，与所有其他组相比，肌肉力量低的肥胖者的步行速度显著降低（P≤0.05）。在纵向分析中，与那些没有肥胖或低肌肉力量的人相比，低肌肉力量的肥胖参与者在6年的随访中行走速度下降更快，发展新的移动残疾的风险更高。80岁以后，组间的差异大大减弱。在低肌肉力量和肥胖组之间观察到的步行速度差异部分解释为肌肉力量，BMI和腰围的6年变化。肥胖与低肌肉力量相结合会增加步行速度下降和发展行动能力障碍的风险，特别是在80岁以下的人中。
Both obesity and muscle impairment are increasingly prevalent among older persons and negatively affect health and physical functioning. However, the combined effect of coexisting obesity and muscle impairment on physical function decline has been little studied. We examined whether obese persons with low muscle strength experience significantly greater declines in walking speed and mobility than persons with only obesity or low muscle strength. Community-dwelling adults aged ≥65 years (n = 930) living in the Chianti geographic area (Tuscany, Italy) were followed for 6 years in the population-based InCHIANTI study. On the basis of baseline measurements (1998−2000), obesity was defined as body mass index (BMI) ≥30 kg/m2 and low muscle strength as lowest sex-specific tertile of knee extensor strength. Walking speed and self-reported mobility disability (ability to walk 400 m or climb one flight of stairs) were assessed at baseline and at 3- and 6-year follow-up. At baseline, obese persons with low muscle strength had significantly lower walking speed compared with all other groups (P≤0.05). In longitudinal analyses, obese participants with low muscle strength had steeper decline in walking speed and high risk of developing new mobility disability over the 6-year follow-up compared with those without obesity or low muscle strength. After the age of 80, the differences between groups were substantially attenuated. The differences seen in walking speed across combination of low muscle strength and obesity groups were partly explained by 6-year changes in muscle strength, BMI and waist circumference. Obesity combined with low muscle strength increases the risk of decline in walking speed and developing mobility disability, especially among persons <80 years old.
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DOI：
10.1093/gerona/60.8.1007
发表时间：
2005-08-01
影响因子：
5.1
作者：
Lee, JS;Kritchevsky, SB;Newman, AB
通讯作者：
Newman, AB
DOI：
10.1111/j.1532-5415.2000.tb03873.x
发表时间：
2000-12-01
影响因子：
6.3
作者：
Ferrucci, L;Bandinelli, S;Guralnik, JM
通讯作者：
Guralnik, JM
DOI：
10.1067/mlc.2001.113504
发表时间：
2001-04-01
期刊：
JOURNAL OF LABORATORY AND CLINICAL MEDICINE
影响因子：
--
作者：
Morley, JE;Baumgartner, RN;Nair, KS
通讯作者：
Nair, KS
影响因子：
120.7
作者：
Alley, Dawn E.;Chang, Virginia W.
通讯作者：
Chang, Virginia W.
影响因子：
3.3
作者：
Schrager, Matthew A.;Metter, E. Jeffrey;Ferrucci, Luigi
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