Diffusion-weighted MRI characteristics associated with prognostic pathological factors and recurrence risk in invasive ER+/HER2- breast cancers.
Diffusion-weighted MRI characteristics associated with prognostic pathological factors and recurrence risk in invasive ER+/HER2- breast cancers.
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DOI：
10.1002/jmri.25909
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发表时间：
2018-07
期刊：
影响因子：
--
通讯作者：
Partridge SC
中科院分区：
文献类型：
--
作者：
Amornsiripanitch N;Nguyen VT;Rahbar H;Hippe DS;Gadi VK;Rendi MH;Partridge SC
激素受体阳性的乳腺癌是最常见的亚型；需要更好的工具来确定这一组中的哪些患者将从化疗中获得明显的好处。通过研究磁共振弥散加权成像(DWI)与病理生物标记物和基因组检测10年复发风险的相关性，评估弥散加权磁共振成像(DWI)的预后潜力。回顾一下。连续107例(2010年2月至2013年1月)ER阳性/HER2Neu阴性浸润性乳腺癌患者接受了21基因复发评分(RS)测试(Oncotype DX，GenomicHealth，Inc.)。所有受试者均于术前行3T乳腺MRI检查，包括弥散加权成像(b=0.800 S/mm~2)。第五年的放射科住院医师测量了每个病变的表观扩散系数(ADC)和对比噪声比(CNR)。病理指标(Nottingham组织学分级、Ki-67、RS)由病理报告确定。回顾医疗记录以评估无复发存活率。RS被分成低(18)、中、高(30)风险组。DWI特征与病理生物标记物的相关性通过适当的二进制或有序Logistic回归进行评估，并对多重比较进行调整。还进行了特定组之间的事后比较。ADC平均值(OR=0.61每1-SD增加，调整P=0.044)和CNR(OR=1.76每1-SD增加，调整P=0.026)与肿瘤分级显著相关。DWI CNR还与高增殖率(Ki-67≥14%)显著相关(OR=2.55每1-SD增加，ADJ。P=0.026)。而在ADC值中没有统计学上显著的线性关联(adj.P=0.80-0.85)和CNR(adj.有序Logistic回归分析表明，与低或中度RS组相比，高RS组的ADC平均值(p=0.037)和ADCmax(p=0.004)较低，CNR较高(p=0.008)。弥散加权成像特征与肿瘤分级、增殖指数和RS相关，可能有助于识别那些复发风险最高和最有可能从化疗中受益的患者。
Hormone receptor positive breast cancer is the most common subtype; better tools to identify which patients in this group would derive clear benefit from chemotherapy are needed. To evaluate the prognostic potential of diffusion-weighted MRI (DWI) by investigating associations with pathologic biomarkers and a genomic assay for 10-year recurrence risk. Retrospective. 107 consecutive patients (from 2/2010 to 1/2013) with ER positive/HER2neu negative invasive breast cancer who had the 21-gene recurrence score (RS) test (Oncotype DX, GenomicHealth, Inc). Each subject underwent pre-surgical 3T breast MRI, which included DWI (b=0, 800 s/mm2). Apparent diffusion coefficient (ADC) and contrast-to-noise ratio (CNR) were measured for each lesion by a fifth year radiology resident. Pathological markers (Nottingham histologic grade, Ki-67, RS) were determined from pathology reports. Medical records were reviewed to assess recurrence-free survival. RS was stratified into low (<18), moderate, and high (>30) risk groups. Associations of DWI characteristics with pathologic biomarkers were evaluated by binary or ordinal logistic regression as appropriate, with adjustment for multiple comparisons. Post-hoc comparisons between specific groups were also performed. ADCmean (OR=0.61 per 1-SD increase, adj. p=0.044) and CNR (OR=1.76 per 1-SD increase, adj. p=0.026) were significantly associated with increasing tumor grade. DWI CNR was also significantly associated with a high (Ki-67≥14%) proliferation rate (OR=2.55 per 1-SD increase, adj. p=0.026). While there were no statistically significant linear associations in ADC (adj. p = 0.80–0.85) and CNR (adj. p=0.56) across all three RS groups by ordinal logistic regression, post-hoc analyses suggested that high RS lesions exhibited lower ADCmean (p=0.037) and ADCmax (p=0.004) values and higher CNR (p=0.008) compared to lesions with a low or moderate RS. DWI characteristics correlated with tumor grade, proliferation index and RS, and may potentially help to identify those with highest recurrence risk and most potential benefit from chemotherapy.
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影响因子：
3.3
作者：
Kitajim, Kazuhiro;Yamano, Toshiko;Hirota, Shozo
通讯作者：
Hirota, Shozo
影响因子：
3.3
作者：
Cipolla, Valentina;Santucci, Domiziana;de Felice, Carlo
通讯作者：
de Felice, Carlo
DOI：
10.1111/j.2517-6161.1995.tb02031.x
发表时间：
1995-01-01
影响因子：
5.8
作者：
BENJAMINI, Y;HOCHBERG, Y
通讯作者：
HOCHBERG, Y
影响因子：
19.7
作者：
Li H;Zhu Y;Burnside ES;Drukker K;Hoadley KA;Fan C;Conzen SD;Whitman GJ;Sutton EJ;Net JM;Ganott M;Huang E;Morris EA;Perou CM;Ji Y;Giger ML
通讯作者：
Giger ML
影响因子：
1.3
作者：
Rahbar H;Kurland BF;Olson ML;Kitsch AE;Scheel JR;Chai X;Usoro J;Lehman CD;Partridge SC
通讯作者：
Partridge SC