One component? Two components? Three? The effect of including a nonexchanging "free" water component in multicomponent driven equilibrium single pulse observation of T1 and T2.
One component? Two components? Three? The effect of including a nonexchanging "free" water component in multicomponent driven equilibrium single pulse observation of T1 and T2.
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DOI：
10.1002/mrm.24429
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发表时间：
2013-07
影响因子：
3.3
通讯作者：
Kolind, Shannon H.
中科院分区：
文献类型：
--
作者：
Deoni, Sean C. L.;Matthews, Lucy;Kolind, Shannon H.
定量髓鞘含量成像提供了与髓鞘相关疾病或异常连接引起的疾病的潜在发病机制相关的新颖和相关信息。T1和T2的多组分驱动平衡单脉冲观测（mcDESPOT）是一种时间效率高的多组分弛豫分析技术，可提供髓鞘水分数（MWF）的估计值，这是髓鞘体积的替代测量值。不幸的是，mcDESPOT依赖于两个水池模型（髓鞘相关水和细胞内/细胞外水），这在部分体积体素（即包含脑组织和脑室或脑膜）内是不充分的，导致MWF低估。为了解决这个问题，第三个，非交换的“自由水”的组件被引入到mcDESPOT模型。数值模拟和体内实验数据表明，该模型在部分体积区域内有利地执行，同时提供稳健和可重复的结果。最后，该模型是更可取的，为未来的研究和分析。
Quantitative myelin content imaging provides novel and pertinent information related to underlying pathogenetic mechanisms of myelin-related disease, or disorders arising from aberrant connectivity. Multicomponent Driven Equilibrium Single Pulse Observation of T1 and T2 (mcDESPOT) is a time-efficient multicomponent relaxation analysis technique that provides estimates of the myelin water fraction (MWF), a surrogate measure of myelin volume. Unfortunately, mcDESPOT relies on a two water-pool model (myelin-associated water, and intra/extra cellular water), which is inadequate within partial-volume voxels, i.e. containing brain tissue and ventricle or meninges, resulting in MWF under-estimation. To address this, a third, non-exchanging ‘free-water’ component was introduced to the mcDESPOT model. Numerical simulations and experimental in vivo data show the model to perform advantageously within partial volume regions whilst providing robust and reproducible results. It is concluded that this model is preferable for future studies and analysis.
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影响因子：
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作者：
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