Local versus long-range connectivity patterns of auditory disturbance in schizophrenia.
Local versus long-range connectivity patterns of auditory disturbance in schizophrenia.
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DOI：
10.1016/j.schres.2020.11.052
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发表时间：
2021-03
影响因子：
4.5
通讯作者：
Hong LE
中科院分区：
文献类型：
--
作者：
Hare SM;Adhikari BM;Du X;Garcia L;Bruce H;Kochunov P;Simon JZ;Hong LE
幻听是精神分裂症的一种衰弱症状。有效的治疗是有限的，因为潜在的神经机制仍然未知。我们的研究探讨了本地和远程功能连接是如何与精神分裂症的听觉知觉障碍（APD）。APD使用听觉感知特质和状态量表进行评估。收集了N=99例精神分裂症患者的静息状态fMRI数据。使用区域同质性（ReHo）分析估计局部功能连接;使用静息状态功能连接（rsFC）分析估计长程连接。中介分析测试是否本地（ReHo）连接显着介导的协会之间的长距离rsFC和APD。APD的严重程度与左右壳核、左颞顶交界处（TPJ）和右丘脑-苍白球的ReHo降低显著相关。较高的APD也与右壳核和对侧壳核和听觉皮层之间的rsFC降低相关。局部和远距离连接测量共同解释APD的40.3%的方差（P < 0.001），最强的预测因子是左侧TPJ ReHo（P < 0.001）。此外，TPJ ReHo显著介导右壳核-左壳核rsFC与APD之间的关系（Sobel检验，P = 0.001）。我们的研究结果表明，本地和远程功能连接缺陷有助于APD，强调纹状体和听觉皮层的作用。考虑到这些基于回路的研究结果在先前临床试验的背景下，以治疗幻听的翻译影响，我们提出了一个模型，其中纠正本地和远距离功能连接缺陷可能是必要的治疗幻听。
Auditory hallucinations are a debilitating symptom of schizophrenia. Effective treatment is limited because the underlying neural mechanisms remain unknown. Our study investigates how local and long-range functional connectivity is associated with auditory perceptual disturbances (APD) in schizophrenia. APD was assessed using the Auditory Perceptual Trait and State Scale. Resting state fMRI data were collected for N=99 patients with schizophrenia. Local functional connectivity was estimated using regional homogeneity (ReHo) analysis; long-range connectivity was estimated using resting state functional connectivity (rsFC) analysis. Mediation analyses tested whether local (ReHo) connectivity significantly mediated associations between long-distance rsFC and APD. Severity of APD was significantly associated with reduced ReHo in left and right putamen, left temporoparietal junction (TPJ), and right hippocampus-pallidum. Higher APD was also associated with reduced rsFC between the right putamen and the contralateral putamen and auditory cortex. Local and long-distance connectivity measures together explained 40.3% of variance in APD (P < 0.001), with the strongest predictor being the left TPJ ReHo (P < 0.001). Additionally, TPJ ReHo significantly mediated the relationship between right putamen – left putamen rsFC and APD (Sobel test, P = 0.001). Our findings suggest that both local and long-range functional connectivity deficits contribute to APD, emphasizing the role of striatum and auditory cortex. Considering the translational impact of these circuit-based findings within the context of prior clinical trials to treat auditory hallucinations, we propose a model in which correction of both local and long-distance functional connectivity deficits may be necessary to treat auditory hallucinations.
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影响因子：
6.6
作者：
Alderson-Day B;Diederen K;Fernyhough C;Ford JM;Horga G;Margulies DS;McCarthy-Jones S;Northoff G;Shine JM;Turner J;van de Ven V;van Lutterveld R;Waters F;Jardri R
通讯作者：
Jardri R
影响因子：
3.1
作者：
Clos M;Diederen KM;Meijering AL;Sommer IE;Eickhoff SB
通讯作者：
Eickhoff SB
影响因子：
4.8
作者：
Adhikari BM;Jahanshad N;Shukla D;Glahn DC;Blangero J;Fox PT;Reynolds RC;Cox RW;Fieremans E;Veraart J;Novikov DS;Nichols TE;Hong LE;Thompson PM;Kochunov P
通讯作者：
Kochunov P
影响因子：
1.9
作者：
BORDI, F;LEDOUX, J;PAVLIDES, C
通讯作者：
PAVLIDES, C
影响因子：
3.7
作者：
Aleman, A;Formisano, E;Kahn, RS
通讯作者：
Kahn, RS