lncRNASNP: a database of SNPs in lncRNAs and their potential functions in human and mouse.
lncRNASNP: a database of SNPs in lncRNAs and their potential functions in human and mouse.
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IncRNASNP：lncRNA 中的 SNP 及其在人类和小鼠中的潜在功能的数据库
DOI：
10.1093/nar/gku1000
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发表时间：
2015-01
影响因子：
14.9
通讯作者：
Guo AY
中科院分区：
文献类型：
--
作者：
Gong J;Liu W;Zhang J;Miao X;Guo AY
长链非编码rna （lncRNAs）通过多种机制在各种细胞环境和疾病中发挥关键作用。随着已鉴定的lncrna和疾病相关单核苷酸多态性（snp）的快速增长，对lncrna中snp的研究需求很大。为了提供有关lncRNA snp的有用资源，我们系统地鉴定了lncRNA中的snp，并分析了它们对lncRNA结构和功能的潜在影响。总共，我们分别在人类和小鼠的30,000多个lncRNA转录本中鉴定出495,729和777,095个snp。大量snp被预测可能影响miRNA-lncRNA相互作用。结合miRNA - lncrna相互作用的实验证据和保守性，以及TCGA的miRNA表达，优先考虑miRNA - lncrna相互作用和结合位点上的snp。此外，通过将snp与GWAS结果进行比对，我们发现142个人类lncRNA snp是GWAS标签snp， 197827个lncRNA snp位于GWAS连锁不平衡区域。所有这些人类和小鼠lncRNAs的数据被导入lncRNASNP数据库（http://bioinfo.life.hust.edu.cn/lncRNASNP/），该数据库包括lncRNASNP-human和lncRNASNP-mouse两个子数据库。lncRNASNP数据库有一个用户友好的界面，用于搜索和浏览SNP、lncRNA和miRNA片段。
Long non-coding RNAs (lncRNAs) play key roles in various cellular contexts and diseases by diverse mechanisms. With the rapid growth of identified lncRNAs and disease-associated single nucleotide polymorphisms (SNPs), there is a great demand to study SNPs in lncRNAs. Aiming to provide a useful resource about lncRNA SNPs, we systematically identified SNPs in lncRNAs and analyzed their potential impacts on lncRNA structure and function. In total, we identified 495 729 and 777 095 SNPs in more than 30 000 lncRNA transcripts in human and mouse, respectively. A large number of SNPs were predicted with the potential to impact on the miRNA–lncRNA interaction. The experimental evidence and conservation of miRNA–lncRNA interaction, as well as miRNA expressions from TCGA were also integrated to prioritize the miRNA–lncRNA interactions and SNPs on the binding sites. Furthermore, by mapping SNPs to GWAS results, we found that 142 human lncRNA SNPs are GWAS tagSNPs and 197 827 lncRNA SNPs are in the GWAS linkage disequilibrium regions. All these data for human and mouse lncRNAs were imported into lncRNASNP database (http://bioinfo.life.hust.edu.cn/lncRNASNP/), which includes two sub-databases lncRNASNP-human and lncRNASNP-mouse. The lncRNASNP database has a user-friendly interface for searching and browsing through the SNP, lncRNA and miRNA sections.
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影响因子：
14.9
作者：
Kozomara A;Griffiths-Jones S
通讯作者：
Griffiths-Jones S
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影响因子：
14.9
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Li JH;Liu S;Zhou H;Qu LH;Yang JH
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3.9
作者：
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Weinberger, Daniel R.
影响因子：
4.4
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影响因子：
4.4
作者：
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