Modulation of the severity of highly pathogenic H5N1 influenza in chickens previously inoculated with Israeli H9N2 influenza viruses.
Modulation of the severity of highly pathogenic H5N1 influenza in chickens previously inoculated with Israeli H9N2 influenza viruses.
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DOI：
10.1016/j.virol.2008.09.026
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发表时间：
2009-01-05
期刊：
影响因子：
3.7
通讯作者：
Webster RG
中科院分区：
文献类型：
--
作者：
Khalenkov A;Perk S;Panshin A;Golender N;Webster RG
H9N2 和 H5N1 病毒的持续进化及其在欧亚大陆的传播和重新出现引起了人们的担忧，即先前的 H9N2 病毒感染可能会减轻疾病的严重程度，从而限制鸡类家禽中后续 H5N1 感染的检测。我们证明 2000 年至 2004 年期间从以色列火鸡中分离出的 H9N2 病毒在抗原性和基因上是可区分的。这三种 H9N2 病毒没有给鸡带来明显的疾病迹象。 2004 年分离株的复制和传播效率最高，之前接种过这种 H9N2 病毒的鸡在接种致命的 H5N1 病毒 1 至 35 天后显示出 90%–100% 的存活率。幸存的鸡没有表现出疾病迹象，但确实从泄殖腔中排出了致命的 H5N1 病毒。生存能力的调节是依赖于时间的；接种 H9N2 后五天效果最大。这些发现表明，H9N2 病毒的共同循环可能有助于致命 H5N1 病毒的传播。
The continued evolution of H9N2 and H5N1 viruses and their spread and re-emergence across Eurasia raise concern that prior H9N2 virus infection may limit the detection of subsequent H5N1 infection in gallinaceous poultry by attenuating the severity of disease. We show that H9N2 viruses isolated from Israeli turkeys during 2000–2004 were antigenically and genetically distinguishable. These three H9N2 viruses caused no overt signs of disease in chickens. The 2004 isolate replicated and spread most efficiently, and chickens previously inoculated with this H9N2 virus showed 90%–100% survival after inoculation 1 to 35 days later with lethal H5N1 virus. Chickens that survived did not show signs of disease but did shed lethal H5N1 virus from the cloaca. The modulation of survivability was time-dependent; the effect was maximal five days after H9N2 inoculation. These findings suggest that co-circulation of H9N2 viruses can contribute to the spread of lethal H5N1 viruses.
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影响因子：
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