Age influences the effects of nicotine and monoamine oxidase inhibition on mood-related behaviors in rats.
Age influences the effects of nicotine and monoamine oxidase inhibition on mood-related behaviors in rats.
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DOI：
10.1007/s00213-009-1760-8
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发表时间：
2010-03
影响因子：
3.4
通讯作者：
Leslie, Frances M.
中科院分区：
文献类型：
--
作者：
Villegier, Anne-Sophie;Gallager, Brittney;Heston, Jon;Belluzzi, James D.;Leslie, Frances M.
流行病学研究表明，吸烟与抑郁和焦虑有共病关系，特别是在青少年时期。然而，很少有动物研究认为尼古丁和其他烟草烟雾成分（如单胺氧化酶（MAO）抑制剂）在情绪调节中可能存在协同作用。本研究的目的是检验尼古丁与不可逆的单胺氧化酶抑制剂反苯环丙胺联合使用对青少年和成年大鼠抑郁和焦虑相关行为的影响差异的假设。尼古丁（0、0.05、0.2 mg/kg，s.c.）和反苯环丙胺（3 mg/kg，i. p.）在出生后30天和68天的雄性大鼠上，分别或一起进行三种情绪相关行为测试：强迫游泳测试（FST）、高架十字迷宫（ESTA）和旷场测试。尼古丁（0.2毫克/公斤）在成人中显着减少浮动时间在FST和增加的时间花在开放臂的的脊髓，没有改变自发活动。反苯环丙胺预处理结合尼古丁（0.2毫克/公斤）显着增加自发活动和时间花费在中心的开放领域。而尼古丁单独对青少年没有显着影响，它显着增加运动活动和减少浮动时间在FST结合反苯环丙胺预处理。尼古丁单独使用和与MAO抑制剂联合使用对情绪相关行为具有年龄依赖性影响。虽然尼古丁单独诱导成年人的情绪改善，但对青少年没有影响。尼古丁与反苯环丙胺联合使用具有独特的年龄依赖性作用。因此，吸烟的实验研究应考虑年龄和其他烟草成分，如单胺氧化酶抑制剂，作为关键因素。
Epidemiological studies have demonstrated a comorbidity of smoking with depression and anxiety, particularly during adolescence. However, few animal studies have considered possible synergistic interactions between nicotine and other tobacco smoke constituents, such as monoamine oxidase (MAO) inhibitors, in the regulation of mood. The aim of the study was to test the hypothesis that nicotine combined with the irreversible MAO inhibitor, tranylcypromine, will differentially affect depression- and anxiety-related behaviors in adolescent and adult rats. Nicotine (0, 0.05, 0.2 mg/kg, s.c.) and tranylcypromine (3 mg/kg, i.p.) were tested separately, or together, on male rats aged postnatal days 30 and 68, in three mood-related behavioral tests: forced swim test (FST), elevated plus maze (EPM), and open field. Nicotine (0.2 mg/kg) in adults significantly decreased floating time in the FST and increased time spent in the open arm of the EPM, with no change in locomotor activity. Tranylcypromine pretreatment combined with nicotine (0.2 mg/kg) significantly increased locomotor activity and time spent in the center of the open field. Whereas nicotine alone had no significant effect on adolescents, it significantly increased locomotor activity and decreased floating time in the FST when combined with tranylcypromine pretreatment. There is an age-dependent effect of nicotine, alone and in combination with MAO inhibition, on mood-related behaviors. Whereas nicotine alone induces mood improvement in adults, it has no effect on adolescents. Nicotine combined with tranylcypromine has unique, age-dependent effects. Thus, experimental studies of smoking should consider both age and other tobacco constituents, such as MAO inhibitors, as critical factors.
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影响因子：
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