Longitudinal patterns of repetitive behavior in toddlers with autism.
Longitudinal patterns of repetitive behavior in toddlers with autism.
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DOI：
10.1111/jcpp.12207
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发表时间：
2014-08
期刊：
影响因子：
--
通讯作者：
IBIS Network
中科院分区：
文献类型：
--
作者：
Wolff JJ;Botteron KN;Dager SR;Elison JT;Estes AM;Gu H;Hazlett HC;Pandey J;Paterson SJ;Schultz RT;Zwaigenbaum L;Piven J;IBIS Network
最近的证据表明，限制性和重复性行为可能会导致婴儿晚期患上自闭症谱系障碍 (ASD) 的儿童有所不同。这些核心症状在生命早期如何表现，特别是在患有该疾病的高危婴儿中，尚不清楚。我们收集了 190 名高风险幼儿和 60 名 12 至 24 个月大的低风险对照儿童的前瞻性纵向家长报告数据（重复行为量表 - 修订版）。 41 名高危儿童在 2 岁时被分类为自闭症谱系障碍。使用广义估计方程比较各组之间的重复行为概况。被诊断患有自闭症谱系障碍的儿童的纵向特征在所有重复行为指标上与未患自闭症谱系障碍的高危和低危儿童存在显着差异。没有自闭症谱系障碍的高风险幼儿是中度到低风险且自闭症谱系障碍阳性的幼儿。在 12 个月的时间点，患有自闭症谱系障碍 (ASD) 的幼儿在不同亚型中表现出明显更高的重复行为率。重复行为与 24 个月大自闭症谱系障碍儿童的适应行为和社交得分显着相关，但与一般认知能力测量基本无关。这些发现表明，早在 12 个月大时，一系列重复行为就在随后发展为自闭症谱系障碍的儿童中显着增加。虽然一定程度的重复行为对于典型的早期发展至关重要，但患有自闭症谱系障碍的儿童中这些行为的程度似乎非常不典型。
Recent evidence suggests that restricted and repetitive behaviors may differentiate children who develop autism spectrum disorder (ASD) by late infancy. How these core symptoms manifest early in life, particularly among infants at high-risk for the disorder, is not well characterized. Prospective, longitudinal parent-report data (Repetitive Behavior Scales-Revised) were collected for 190 high-risk toddlers and 60 low-risk controls from 12 to 24 months age. Forty-one high-risk children were classified with ASD at age 2. Profiles of repetitive behavior were compared between groups using generalized estimating equations. Longitudinal profiles for children diagnosed with ASD differed significantly from high- and low-risk children without the disorder on all measures of repetitive behavior. High-risk toddlers without ASD were intermediate to low-risk and ASD positive counterparts. Toddlers with ASD showed significantly higher rates of repetitive behavior across subtypes at the 12 month time point. Repetitive behaviors were significantly correlated with adaptive behavior and socialization scores among children with ASD at 24 months-age but were largely unrelated to measures of general cognitive ability. These findings suggest that as early as 12 months age, a broad range of repetitive behaviors are highly elevated in children who go on to develop ASD. While some degree of repetitive behavior is elemental to typical early development, the extent of these behaviors among children who develop ASD appears highly atypical.
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