Effect of blood T1 estimation strategy on arterial spin labeled cerebral blood flow quantification in children and young adults with kidney disease.
Effect of blood T1 estimation strategy on arterial spin labeled cerebral blood flow quantification in children and young adults with kidney disease.
复制标题
血液T1估计策略对肾脏疾病儿童和年轻人的动脉自旋标记的动脉旋转的影响。
DOI：
10.1016/j.neurad.2018.03.002
复制
发表时间：
2019-03
期刊：
影响因子：
--
通讯作者：
Detre JA
中科院分区：
文献类型：
--
作者：
Liu HS;Jawad AF;Laney N;Hartung EA;Furth SL;Detre JA
在慢性肾脏病（CKD）贫血患者和对照组的发育队列中，比较用于定量脑血流量（CBF）的血液T1估计方法与动脉自旋标记（ASL）灌注MRI。研究了61例CKD患者和47例年龄匹配的对照组。血液T1方法包括：（1）固定值，（2）基于测量的红细胞压积（Hct）的估计值，以及（3）使用公开公式基于年龄+性别的估计值。沿着比较T1和CBF值以及组、年龄和性别效应。当使用Hct校正的血液T1时，使用固定血液T1的CBF中高度显着的组间差异有所减少，而当使用年龄+性别估计方法时，则完全消除。在对照队列中，固定T1法显示CBF与年龄和性别的相关性最强。Hct校正的T1保留了CBF与年龄和性别之间的显着相关性，而年龄+性别估计的T1产生的CBF与年龄和性别的拟合较差。血液T1估计方法可能混淆CKD患者使用ASL MRI测量的CBF变化的解释。在贫血的临床人群中，理想情况下应校正血T1对红细胞压积的影响。
To compare blood T1 estimation approaches used for quantifying cerebral blood flow (CBF) with arterial spin labeled (ASL) perfusion MRI in a developmental cohort of chronic kidney disease (CKD) patients with anemia and a control group. 61 patients with CKD and 47 age-matched control subjects were studied. Blood T1 approaches included: (1) a fixed value, (2) estimation based on measured hematocrit (Hct), and (3) estimation based on Age+Sex using a published formula. Resulting T1 and CBF values were compared along with group, age and sex effects. Highly significant group differences in CBF using fixed blood T1 were reduced when Hct-corrected blood T1 was used, and were eliminated entirely when using the Age+Sex estimated approach. In the control cohort, fixed T1 method showed the strongest correlations of CBF with age and sex. Hct-corrected T1 preserved a significant correlation between CBF and age and sex, while Age+Sex estimated T1 produced a poor fit of CBF with age and sex. Blood T1 estimation method can confound the interpretation of CBF changes measured using ASL MRI in patients with CKD. Blood T1 should ideally be corrected for hematocrit effects in clinical populations with anemia.
登录
查看更多内容
影响因子：
19.6
作者：
Kuwabara, Y;Sasaki, M;Fujishima, M
通讯作者：
Fujishima, M
影响因子：
14.5
作者：
LEENDERS, KL;PERANI, D;JONES, T
通讯作者：
JONES, T
影响因子：
9.9
作者：
Tamura, Manjula Kurella;Pajewski, Nicholas M.;Zaharchuk, Greg
通讯作者：
Zaharchuk, Greg
影响因子：
3.3
作者：
Silvennoinen, MJ;Kettunen, MI;Kauppinen, RA
通讯作者：
Kauppinen, RA
影响因子：
19.6
作者：
通讯作者：
--