Alcohol and pharmacologically similar sedatives impair encoding and facilitate consolidation of both recollection and familiarity in episodic memory.
Alcohol and pharmacologically similar sedatives impair encoding and facilitate consolidation of both recollection and familiarity in episodic memory.
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DOI：
10.1080/17588928.2018.1504764
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发表时间：
2018-07
影响因子：
2
通讯作者：
De Wit H
中科院分区：
文献类型：
--
作者：
Doss MK;Weafer J;Ruiz NA;Gallo DA;De Wit H
Alcohol and other pharmacologically similar sedatives (i.e., GABAA positive allosteric modulators or PAMs) impair the encoding of new episodic memories but retroactively facilitate the consolidation of recently encoded memories. These effects are consistent for recollection (i.e., the retrieval of details) but some mixed results have been reported for familiarity (i.e., a feeling of knowing a stimulus was presented). Here, with dual-process models, we reanalyzed prior work testing the effects of GABAA PAMs at encoding or consolidation. Contrary to previous conclusions, we show that GABAA PAMs at encoding consistently impair both recollection and familiarity when an independence correction is applied to familiarity-based responses. These findings were further confirmed and extended in a dual-process signal detection analysis of a recent study on the effects of alcohol during encoding or consolidation: Alcohol at encoding impaired both recollection and familiarity, whereas alcohol at consolidation enhanced both recollection and familiarity. These findings speak to the ability of alcohol and other GABAA PAMs to induce ‘blackouts,’ highlighting the importance of dual-process approaches when analyzing drug manipulations at different phases of episodic memory.
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影响因子：
3.4
作者：
Huron, C;Servais, C;Danion, JM
通讯作者：
Danion, JM
影响因子：
3.4
作者：
Ballard, Michael E.;Gallo, David A.;de Wit, Harriet
通讯作者：
de Wit, Harriet
DOI：
10.1523/jneurosci.3127-12.2013
发表时间：
2013-03-06
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Mednick SC;McDevitt EA;Walsh JK;Wamsley E;Paulus M;Kanady JC;Drummond SP
通讯作者：
Drummond SP
影响因子：
2.4
作者：
Curran, HV;Hildebrandt, M
通讯作者：
Hildebrandt, M
影响因子：
5.4
作者：
Koen, Joshua D.;Barrett, Frederick S.;Yonelinas, Andrew P.
通讯作者：
Yonelinas, Andrew P.