RotaC: a web-based tool for the complete genome classification of group A rotaviruses.
RotaC: a web-based tool for the complete genome classification of group A rotaviruses.
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DOI：
10.1186/1471-2180-9-238
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发表时间：
2009-11-23
期刊：
影响因子：
4.2
通讯作者：
Van Ranst M
中科院分区：
文献类型：
--
作者：
Maes P;Matthijnssens J;Rahman M;Van Ranst M
A组轮状病毒是全球婴儿和儿童严重腹泻的最常见原因，并继续对儿童发病率和死亡率产生重大全球影响。近年来，大量的研究工作致力于开发两种新的口服活疫苗。虽然这两种疫苗已被证明对严重的轮状病毒胃肠炎具有良好的保护作用，但这些疫苗必须进行筛选，并可能必须定期更新，以反映时间和空间的基因型波动。在这个问题上，循环和新出现的轮状病毒株的遗传特征将需要是强制性的和准确的。最近提出了一个扩展的轮状病毒分类系统，其中使用了所有11个基因组RNA片段。该分类系统的使用将有助于阐明基因表达在遗传多样性的产生、寄主范围的限制、某些基因片段的共分离以及对新寄主物种的适应中的作用。在这里，我们提出了一个基于网络的工具，可用于快速轮状病毒基因型分化的所有11组A轮状病毒基因片段根据轮状病毒分类工作组（RCWG）提出的新的指导方针。随着世界各地越来越多的测序工作正在进行，以解开人类和动物源的完整轮状病毒基因组，该工具将有助于分析和正确分类大量的新数据。这个基于网络的工具可在http://rotac.regatools.be上免费获得。
Group A rotaviruses are the most common cause of severe diarrhea in infants and children worldwide and continue to have a major global impact on childhood morbidity and mortality. In recent years, considerable research efforts have been devoted to the development of two new live, orally administered vaccines. Although both vaccines have proven to confer a good protection against severe rotavirus gastroenteritis, these vaccines will have to be screened and may have to be updated regularly to reflect temporal and spatial genotype fluctuations. In this matter, the genetic characterization of circulating and new emerging rotavirus strains will need to be compulsory and accurate. An extended classification system for rotaviruses in which all the 11 genomic RNA segments are used, has been proposed recently. The use of this classification system will help to elucidate the role of gene reassortments in the generation of genetic diversity, host range restriction, co-segregation of certain gene segments, and in adaptation to a new host species. Here we present a web-based tool that can be used for fast rotavirus genotype differentiation of all 11 group A rotavirus gene segments according to the new guidelines proposed by the Rotavirus Classification Working Group (RCWG). With the increasing sequencing efforts that are being conducted around the world to unravel complete rotavirus genomes of human and animal origin, this tool will be of great help to analyze and correctly classify the large amount of new data. The web-based tool is freely available at http://rotac.regatools.be.
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影响因子：
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使用所有11个基因组RNA片段的轮状病毒组分类的建议。
影响因子：
2.7
作者：
Matthijnssens, Jelle;Ciarlet, Max;Rahman, Mustafizur;Attoui, Houssam;Banyai, Krisztian;Estes, Mary K.;Gentsch, Jon R.;Iturriza-Gomara, Miren;Kirkwood, Carl D.;Martella, Vito;Mertens, Peter P. C.;Nakagomi, Osamu;Patton, John T.;Ruggeri, Franco M.;Saif, Linda J.;Santos, Norma;Steyer, Andrej;Taniguchi, Koki;Desselberger, Ulrich;Van Ranst, Marc
通讯作者：
Van Ranst, Marc
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作者：
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通讯作者：
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