Key Factors That Enable the Pandemic Potential of RNA Viruses and Inter-Species Transmission: A Systematic Review.
Key Factors That Enable the Pandemic Potential of RNA Viruses and Inter-Species Transmission: A Systematic Review.
复制标题
使RNA病毒的大流行潜力和物种间传播成为可能的关键因素：系统评价。
DOI：
10.3390/v13040537
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发表时间：
2021-03-24
期刊：
影响因子：
--
通讯作者：
Ramirez-Nieto G
中科院分区：
文献类型：
--
作者：
Alvarez-Munoz S;Upegui-Porras N;Gomez AP;Ramirez-Nieto G
病毒在全球大流行中起着主要的病原作用。尽管在确定病毒和宿主的分子特征方面取得了进展，但这些因素和其他因素对物种间传播的影响程度以及它们与疾病出现的关系仍知之甚少。本综述的目的是分析过去20年导致大流行的RNA病毒固有特征的相关因素，这些特征促进了感染，促进了种间跳跃，并有助于产生具有大流行潜力的人畜共患感染。检索结果为48篇符合纳入标准的研究文章。RNA病毒所采取的变化受到环境和宿主相关因素的影响，这些因素决定了它们的适应能力。人口密度、宿主分布、迁移模式和自然栖息地的丧失等都是病毒-宿主相互作用的相关因素。考虑到拉丁美洲多样化和独特的社会、文化和生物多样性特征，本综述还包括对拉丁美洲环境的批判性分析。科学信息的缺乏是惊人的，因此，呼吁地方机构和政府投入更多的资源和努力来研究该地区的这些因素是关键。
Viruses play a primary role as etiological agents of pandemics worldwide. Although there has been progress in identifying the molecular features of both viruses and hosts, the extent of the impact these and other factors have that contribute to interspecies transmission and their relationship with the emergence of diseases are poorly understood. The objective of this review was to analyze the factors related to the characteristics inherent to RNA viruses accountable for pandemics in the last 20 years which facilitate infection, promote interspecies jump, and assist in the generation of zoonotic infections with pandemic potential. The search resulted in 48 research articles that met the inclusion criteria. Changes adopted by RNA viruses are influenced by environmental and host-related factors, which define their ability to adapt. Population density, host distribution, migration patterns, and the loss of natural habitats, among others, have been associated as factors in the virus–host interaction. This review also included a critical analysis of the Latin American context, considering its diverse and unique social, cultural, and biodiversity characteristics. The scarcity of scientific information is striking, thus, a call to local institutions and governments to invest more resources and efforts to the study of these factors in the region is key.
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