Hydrogel-assisted neuroregeneration approaches towards brain injury therapy: A state-of-the-art review.
Hydrogel-assisted neuroregeneration approaches towards brain injury therapy: A state-of-the-art review.
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DOI：
10.1016/j.csbj.2018.10.011
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发表时间：
2018
影响因子：
6
通讯作者：
Timashev PS
中科院分区：
文献类型：
--
作者：
Kornev VA;Grebenik EA;Solovieva AB;Dmitriev RI;Timashev PS
近年来，各种基于水凝胶的神经再生系统得到了发展。这些三维网络由亲水性聚合物组成，由高达90%的水组成，是脑组织再生的有前途的工具。它们可以通过提供机械支持和引导细胞命运来帮助受损组织的结构和功能修复。由于其广泛可调的物理、化学和生物特性，水凝胶也显示出脑损伤治疗的潜力。在最近的脑损伤修复研究中广泛应用的水凝胶聚合物包括透明质酸、I型胶原蛋白、海藻酸盐、壳聚糖、甲基纤维素、基质蛋白、纤维蛋白、结冷胶、自组装肽和蛋白质、聚乙二醇、甲基丙烯酸酯和甲基丙烯酰胺。作为神经再生的工具，水凝胶可以分为：(1)适合脑损伤治疗的水凝胶；(2)不满足基本治疗要求的水凝胶；(3)有前景的、满足进一步研究标准的水凝胶。我们的分析表明，纤维蛋白，胶原I和自组装肽基水凝胶显示出非常有吸引力的神经再生特性。
Recent years have witnessed the development of an enormous variety of hydrogel-based systems for neuroregeneration. Formed from hydrophilic polymers and comprised of up to 90% of water, these three-dimensional networks are promising tools for brain tissue regeneration. They can assist structural and functional restoration of damaged tissues by providing mechanical support and navigating cell fate. Hydrogels also show the potential for brain injury therapy due to their broadly tunable physical, chemical, and biological properties. Hydrogel polymers, which have been extensively implemented in recent brain injury repair studies, include hyaluronic acid, collagen type I, alginate, chitosan, methylcellulose, Matrigel, fibrin, gellan gum, self-assembling peptides and proteins, poly(ethylene glycol), methacrylates, and methacrylamides. When viewed as tools for neuroregeneration, hydrogels can be divided into: (1) hydrogels suitable for brain injury therapy, (2) hydrogels that do not meet basic therapeutic requirements and (3) promising hydrogels which meet the criteria for further investigations. Our analysis shows that fibrin, collagen I and self-assembling peptide-based hydrogels display very attractive properties for neuroregeneration.
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