Thrombotic markers in metabolic syndrome subjects exposed to diesel exhaust.
Thrombotic markers in metabolic syndrome subjects exposed to diesel exhaust.
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DOI：
10.1080/08958370802074908
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发表时间：
2008-08
影响因子：
2.1
通讯作者：
Sullivan JH
中科院分区：
文献类型：
--
作者：
Carlsten C;Kaufman JD;Trenga CA;Allen J;Peretz A;Sullivan JH
肺源性颗粒物（PM）与心血管疾病的发病率和死亡率有关，但其机制尚不清楚。在流行病学和动物模型中，血栓形成前过程与PM有关，但在对照人类模型中并不一致。柴油机尾气是PM的主要来源。我们在代谢综合征受试者中进行了DE的对照人体暴露。研究目的是评价DE暴露对易患心血管疾病人群中血栓前标志物的影响。采用随机、交叉、双盲设计：16例代谢综合征受试者在3个不同日期（≥2周洗脱期）暴露于DE 0（过滤空气，FA）、100 μg PM2.5/m3（DE 100）和200 μg PM2.5/m3（DE 200）。我们评估了暴露开始后3、7和22小时D-二聚体、血管性血友病因子（VWF）和纤溶酶激活剂抑制剂-1（派-1）的DE相关变化。在7 h时观察到VWF的DE 200可归因降低（1.17倍; CI 1.04 - 1.34）。其他主要终点未发生显著变化。如先前在健康受试者中所注意到的，观察到派-1的强昼夜模式。因此，在一项新的研究中，我们无法证明中等剂量的柴油机废气暴露对心血管疾病风险人群的促血栓形成作用。
Traffic-derived particulate matter (PM) is associated with cardiovascular morbidity and mortality, but the mechanism of this association is unclear. Prothrombotic processes have been linked to PM in epidemiological and animal models, but have not been consistently implicated in controlled human models. Diesel exhaust (DE) is a major contributor to PM. We conducted a controlled human exposure of DE in subjects with metabolic syndrome. The study objective was to evaluate DE exposure effects on prothrombotic markers in a population vulnerable to cardiovascular disease. A randomized, crossover, double-blinded design was used: 16 subjects with metabolic syndrome exposed on 3 different days (≥2 wk washout) to DE at 0 (filtered air, FA), 100 μg PM2.5/m3 (DE100) and 200 μg PM2.5/m3 (DE200). We assessed DE-associated changes in D-dimer, von Willebrand factor (VWF), and plasmin activator inhibitor-1 (PAI-1) at 3, 7, and 22 h after exposure initiation. A DE200-attributable decrease (1.17-fold; CI 1.04 to 1.34) in VWF was noted at 7 h. Significant changes did not occur in other primary endpoints. As previously noted with healthy subjects, strong diurnal patterns in PAI-1 were observed. Thus, in a novel study, we were unable to demonstrate a prothrombotic effect of moderate-dose diesel exhaust exposure in a population at risk for cardiovascular disease.
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影响因子：
168.9
作者：
Peters, A;Doring, A;Koenig, W
通讯作者：
Koenig, W
影响因子：
10.4
作者：
Rückerl R;Greven S;Ljungman P;Aalto P;Antoniades C;Bellander T;Berglind N;Chrysohoou C;Forastiere F;Jacquemin B;von Klot S;Koenig W;Küchenhoff H;Lanki T;Pekkanen J;Perucci CA;Schneider A;Sunyer J;Peters A;AIRGENE Study Group
通讯作者：
AIRGENE Study Group
影响因子：
7.5
作者：
Sinkovic, A;Pogacar, V
通讯作者：
Pogacar, V
影响因子：
8.3
作者：
Goldberg, MS;Burnett, RT;Brook, JR
通讯作者：
Brook, JR
影响因子：
15.9
作者：
Mutlu, Goekhan M.;Green, David;Budinger, G. R. Scott
通讯作者：
Budinger, G. R. Scott