Eye-tracking in amyotrophic lateral sclerosis: A longitudinal study of saccadic and cognitive tasks.
Eye-tracking in amyotrophic lateral sclerosis: A longitudinal study of saccadic and cognitive tasks.
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DOI：
10.3109/21678421.2015.1054292
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发表时间：
2015
影响因子：
2.8
通讯作者：
Turner MR
中科院分区：
文献类型：
--
作者：
Proudfoot M;Menke RA;Sharma R;Berna CM;Hicks SL;Kennard C;Talbot K;Turner MR
在ALS中，眼球运动的相对保留是值得注意的，但扫视功能尚未被纵向研究。ALS与FTD重叠，通常涉及执行功能障碍，眼动追踪为评估书写和说话受损的运动外病理提供了额外的潜力。眼动跟踪测量（包括反扫视，跟踪和视觉搜索任务）进行了评估，每六个月的时间间隔长达两年的一组ALS（n = 61）和原发性侧索硬化症（n = 7）的患者，与健康的年龄匹配的对照组（n = 39）在一个单一的场合进行了评估。推测性地探讨了与静息态功能性MRI（R-FMRI）网络连接有关的任务表现。结果表明，ALS患者受损的执行和视觉搜索任务，尽管正常的基本扫视功能，和PLS患者的障碍往往是出乎意料的更严重。在两组中均未检测到纵向显著进展。没有发现R-FMRI网络连接与患者表现相关的变化。总之，眼动追踪提供了一个客观的手段来评估ALS的运动外脑参与。纯眼功能的相对阻力得到证实，更高级别的执行障碍并不遵循与身体残疾相同的下降速度。PLS患者可能有更多的皮质功能障碍比以前已经认识到。
A relative preservation of eye movements is notable in ALS, but saccadic functions have not been studied longitudinally. ALS overlaps with FTD, typically involving executive dysfunction, and eye-tracking offers additional potential for the assessment of extramotor pathology where writing and speaking are both impaired. Eye-tracking measures (including anti-saccade, trail-making and visual search tasks) were assessed at six-monthly intervals for up to two years in a group of ALS (n = 61) and primary lateral sclerosis (n = 7) patients, compared to healthy age-matched controls (n = 39) assessed on a single occasion. Task performance was explored speculatively in relation to resting-state functional MRI (R-FMRI) network connectivity. Results showed that ALS patients were impaired on executive and visual search tasks despite normal basic saccadic function, and impairments in the PLS patients were unexpectedly often more severe. No significant progression was detected longitudinally in either group. No changes in R-FMRI network connectivity were identified in relation to patient performance. In conclusion, eye-tracking offers an objective means to assess extramotor cerebral involvement in ALS. The relative resistance of pure oculomotor function is confirmed, and higher-level executive impairments do not follow the same rate of decline as physical disability. PLS patients may have more cortical dysfunction than has been previously appreciated.
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影响因子：
3.7
作者：
Canu E;Agosta F;Galantucci S;Chiò A;Riva N;Silani V;Falini A;Comi G;Filippi M
通讯作者：
Filippi M
影响因子：
2
作者：
Anderson, E. J.;Mannan, S. K.;Kennard, C.
通讯作者：
Kennard, C.
影响因子：
4.2
作者：
Agosta, Federica;Canu, Elisa;Filippi, Massimo
通讯作者：
Filippi, Massimo
影响因子：
14.5
作者：
Douaud, Gwenaelle;Filippini, Nicola;Turner, Martin R.
通讯作者：
Turner, Martin R.
影响因子：
--
作者：
Boxer, Adam L.;Garbutt, Siobhan;Miller, Bruce L.
通讯作者：
Miller, Bruce L.