Role of IgA in the early-life establishment of the gut microbiota and immunity: Implications for constructing a healthy start.
Role of IgA in the early-life establishment of the gut microbiota and immunity: Implications for constructing a healthy start.
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DOI：
10.1080/19490976.2021.1908101
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发表时间：
2021-01
期刊：
影响因子：
12.2
通讯作者：
Zhan J
中科院分区：
文献类型：
--
作者：
Guo J;Ren C;Han X;Huang W;You Y;Zhan J
肠道微生物区系(GM)在生命早期的定植和成熟是一个里程碑式的事件，它从根本上影响各种哺乳动物的(早期)免疫和晚年健康。这是一个微妙的系统过程，受到婴儿及其母亲的生物主动调节，其中(分泌性)IgA可能发挥关键作用。(分泌性)IgA是母乳中发现的并由婴儿主动产生的微生物的重要调节因子。通过与微生物结合，IgA可以抑制或增强微生物的定植，影响微生物的基因表达，调节免疫反应。早期生命中的IGA功能障碍与GM成熟中断和各种微生物相关疾病有关，如坏死性小肠结肠炎和腹泻，这些疾病也可能对GM和宿主健康产生持久影响。本文讨论了GM的早期成熟过程及其与免疫的相互作用，以及IgA(主要是乳汁分泌型IgA)在调节这一过程中的作用。这一知识在促进正常的转基因成熟过程和免疫教育方面的可能应用也得到了强调。
Colonization and maturation of the gut microbiota (GM) during early life is a landmark event that fundamentally influences the (early) immunity and later-life health of various mammals. This is a delicate, systematic process that is biologically actively regulated by infants and their mothers, where (secretory) IgA, an important regulator of microbes found in breast milk and generated actively by infants, may play a key role. By binding to microbes, IgA can inhibit or enhance their colonization, influence their gene expression, and regulate immune responses. IgA dysfunction during early life is associated with disrupted GM maturation and various microbe-related diseases, such as necrotizing enterocolitis and diarrhea, which can also have a lasting effect on GM and host health. This review discusses the process of early GM maturation and its interaction with immunity and the role of IgA (focusing on milk secretory IgA) in regulating this process. The possible application of this knowledge in promoting normal GM maturation processes and immune education has also been highlighted.
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DOI：
10.1155/2015/737294
发表时间：
2015-03
期刊：
The Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale
影响因子：
--
作者：
Dong XD;Li XR;Luan JJ;Liu XF;Peng J;Luo YY;Liu CJ
通讯作者：
Liu CJ
影响因子：
32.4
作者：
Bunker JJ;Flynn TM;Koval JC;Shaw DG;Meisel M;McDonald BD;Ishizuka IE;Dent AL;Wilson PC;Jabri B;Antonopoulos DA;Bendelac A
通讯作者：
Bendelac A
影响因子：
17.1
作者：
Arrieta, Marie-Claire;Stiemsma, Leah T.;Finlay, B. Brett
通讯作者：
Finlay, B. Brett
影响因子：
3.9
作者：
Akagawa, Shohei;Tsuji, Shoji;Kaneko, Kazunari
通讯作者：
Kaneko, Kazunari
DOI：
10.1111/1471-0528.15799
发表时间：
2020-01-01
影响因子：
5.8
作者：
Coker, M. O.;Hoen, A. G.;Madan, J. C.
通讯作者：
Madan, J. C.