Work-related maternal risk factors and the risk of pregnancy induced hypertension and preeclampsia during pregnancy. The Generation R Study.
Work-related maternal risk factors and the risk of pregnancy induced hypertension and preeclampsia during pregnancy. The Generation R Study.
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DOI：
10.1371/journal.pone.0039263
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发表时间：
2012
期刊：
影响因子：
3.7
通讯作者：
Burdorf A
中科院分区：
文献类型：
--
作者：
Nugteren JJ;Snijder CA;Hofman A;Jaddoe VW;Steegers EA;Burdorf A
为了在一项大型出生队列研究中研究怀孕期间体力要求高的工作和职业暴露与高血压疾病的关系，R世代研究。在荷兰，4465名孕妇参加了一项基于人群的前瞻性队列研究，从怀孕早期开始(2002-2006年)，研究了职业特征与妊娠期高血压疾病的关系。在怀孕中期填写调查问卷的母亲(回答为登记人数的77%)，如果她们从事有偿就业，有自发怀孕的独生子女，并且没有既往存在的高血压(n = 4465)。关于体力要求高的工作的问题来自荷兰肌肉骨骼问卷，涉及手动处理25公斤或更多的负荷、长时间站立或行走、夜班和工作时间等问题。为了评估职业接触化学品，将职称和任务说明与职业接触矩阵联系起来，这是对工作场所接触化学品的专家判断。关于妊娠期高血压疾病的信息从医疗记录中获得。我们没有观察到任何与工作相关的风险因素，如长时间站立或行走、举重、夜班和工作时间，也没有在怀孕期间暴露于化学物质与高血压疾病之间的一致联系。这项前瞻性出生队列研究表明，妊娠期高血压疾病与繁重的工作或接触化学物质没有关联。然而，妊高征和PE的低患病率，加上职业危险因素的低患病率，限制了推断的能力，需要更大的研究来证实或驳斥这些发现。
To study the associations between physically demanding work and occupational exposure to chemicals and hypertensive disorders during pregnancy within a large birth cohort study, the Generation R Study. Associations between occupational characteristics and hypertensive disorders during pregnancy were studied in 4465 pregnant woman participating in a population-based prospective cohort study from early pregnancy onwards in the Netherlands (2002–2006). Mothers who filled out a questionnaire during mid-pregnancy (response 77% of enrolment), were included if they conducted paid employment, had a spontaneously conceived singleton live born pregnancy, and did not suffer from pre-existing hypertension (n = 4465). Questions on physical demanding work were obtained from the Dutch Musculoskeletal Questionnaire and concerned questions on manually handling loads of 25 kg or more, long periods of standing or walking, night shifts, and working hours. To assess occupational exposure to chemicals, job titles and task descriptions were linked to a job-exposure-matrix (JEM), an expert judgment on exposure to chemicals at the workplace. Information on hypertensive disorders during pregnancy was obtained from medical records. We observed no consistent associations between any of the work related risk factors, such as long periods of standing or walking, heavy lifting, night shifts, and working hours, nor exposure to chemicals with hypertensive disorders during pregnancy. This prospective birth cohort study suggests that there is no association of hypertensive disorders during pregnancy with physically demanding work or exposure to chemicals. However, the low prevalence of PIH and PE, combined with the low prevalence of occupational risk factors limit the power for inference and larger studies are needed to corroborate or refute these findings.
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影响因子：
7.2
作者：
Coolman, Marianne;de Groot, Christianne J. M.;Steegers, Eric A. P.
通讯作者：
Steegers, Eric A. P.
影响因子：
13.6
作者：
Jaddoe, Vincent W. V.;Mackenbach, Johan P.;Hofman, Albert
通讯作者：
Hofman, Albert
影响因子：
3.5
作者：
ESKENAZI, B;BRACKEN, MB;GRADY, J
通讯作者：
GRADY, J
影响因子：
2.4
作者：
Hildebrandt, VH;Bongers, PM;Dul, J
通讯作者：
Dul, J
影响因子：
4.9
作者：
Brouwers, M. M.;van Tongeren, M.;Roeleveld, N.
通讯作者：
Roeleveld, N.