Quality of life in people living with HIV-associated neurocognitive disorder: A scoping review study.
Quality of life in people living with HIV-associated neurocognitive disorder: A scoping review study.
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DOI：
10.1371/journal.pone.0251944
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发表时间：
2021
期刊：
影响因子：
3.7
通讯作者：
Vera JH
中科院分区：
文献类型：
--
作者：
Alford K;Daley S;Banerjee S;Vera JH
生活质量（QoL）被认为是慢性疾病（如艾滋病毒）疾病管理的重要终点，呼吁将良好的QoL作为世界卫生组织2016年推出的90-90-90检测和治疗目标中的“第四个90”。认知障碍影响广泛的经验，是影响艾滋病毒感染者（PLWH）的常见问题。尽管如此，很少有研究探讨生活质量在PLWH谁也有认知障碍。本研究旨在综合和描述HIV相关神经认知障碍（HAND）患者的生活质量。对同行评审文献进行了范围审查，以确定如何在PLWH伴HAND中研究和测量QoL，以及PLWH伴HAND如何报告和描述其QoL。我们检索了PsychInfo、Medline、Scopus和Web of Science沿着相关研究的手工检索参考文献列表，纳入的研究是2003年1月1日之后以英文发表的，其中包括PLWH伴认知障碍，而不是由于其他预先存在的疾病。15篇文章符合纳入标准。两项研究将生活质量作为主要目标，其他研究将生活质量评估作为更广泛结局的一部分。MOS-HIV和SF-36是最常用的总体生活质量指标，结果通常表明，与不伴认知障碍的PLWH相比，伴HAND的PLWH的总体生活质量较差。研究生活质量的维度只集中在功能，独立性水平和心理生活质量领域。有一个相当缺乏的研究，检查生活质量PLWH与手。倡导健康老龄化和改善PLWH生活质量的举措必须扩展到包括和理解那些也患有认知障碍的人的经历。需要研究来了解这两种复杂的慢性疾病的广泛经验影响，以确保干预措施对患者有意义，并且不会错过潜在的好处。
Quality of life (QoL) is recognized as an essential end point in the disease management of chronic conditions such as HIV with calls to include good QoL as a ‘fourth 90’ in the 90-90-90 testing and treatment targets introduced by World Health Organization in 2016. Cognitive impairments impact a broad spectrum of experiences and are a common issue effecting people living with HIV (PLWH). Despite this, few studies have examined QoL in PLWH who also have a cognitive disorder. This study aimed to synthesize and describe what is known about QoL in those living with HIV-associated neurocognitive disorders (HAND). A scoping review of peer-reviewed literature was conducted to identify how QoL has been investigated and measured in PLWH with HAND, and how PLWH with HAND report and describe their QoL. We searched PsychInfo, Medline, Scopus, and Web of Science along with hand-searching reference lists from relevant studies found. Included studies were those published in English after 1st January 2003 which included PLWH with cognitive impairment not due to other pre-existing conditions. Fifteen articles met criteria for inclusion. Two studies measured QoL as a primary aim, with others including QoL assessment as part of a broader battery of outcomes. The MOS-HIV and SF-36 were the most commonly used measures of overall QoL, with findings generally suggestive of poorer overall QoL in PLWH with HAND, compared to PLWH without cognitive impairment. Studies which examined dimensions of QoL focused exclusively on functionality, level of independence, and psychological QoL domains. There is a considerable dearth of research examining QoL in PLWH with HAND. The initiatives which advocate for healthy aging and improved QoL in PLWH must be extended to include and understand the experiences those also living with cognitive impairment. Research is needed to understand the broad experiential impacts of living with these two complex, chronic conditions, to ensure interventions are meaningful to patients and potential benefits are not missed.
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影响因子：
3.2
作者：
Gandhi, Nishiena S.;Skolasky, Richard L.;Peters, Katherine B.;Moxley, Richard T.;Creighton, Jason;Roosa, Heidi Vornbrock;Selnes, Ola A.;McArthur, Justin;Sacktor, Ned
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通讯作者：
Walton, P
影响因子：
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通讯作者：
Fuhrer, MJ