Effects of high fat diet on Morris maze performance, oxidative stress, and inflammation in rats: contributions of maternal diet.
Effects of high fat diet on Morris maze performance, oxidative stress, and inflammation in rats: contributions of maternal diet.
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DOI：
10.1016/j.nbd.2009.04.002
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发表时间：
2009-07
影响因子：
6.1
通讯作者：
Bruce-Keller AJ
中科院分区：
文献类型：
--
作者：
White CL;Pistell PJ;Purpera MN;Gupta S;Fernandez-Kim SO;Hise TL;Keller JN;Ingram DK;Morrison CD;Bruce-Keller AJ
本研究旨在探讨出生前后暴露于高脂饮食对大脑的影响。在繁殖前4周以及整个妊娠期和哺乳期将雌性大鼠分为高脂饮食（HFD）组和对照饮食（CD）组。断奶后，将雄性后代置于普通饲料中直至8周龄，然后分成HFD或CD组。在20周龄时，在Morris水迷宫中评估大鼠，并记录大脑中的氧化应激和炎症标志物。与喂食CD的大鼠相比，来自HFD母鼠的HFD子代的认知下降表现为在水迷宫中保持能力下降，但不表现为获得能力下降。HFD还与3-硝基酪氨酸、诱导型一氧化氮合酶、IL-6和神经胶质标志物Iba-1和GFAP的显著增加相关，其中最大的增加经常在HFD母鼠所生的HFD动物中观察到。因此，这些数据共同表明，HFD增加脑中的氧化和炎症信号传导，并进一步表明母体HFD消耗可能使后代对HFD的有害作用敏感。
This study was undertaken to investigate the effects of prenatal and postnatal exposure to high fat diet on the brain. Female rats were divided into high fat diet (HFD) and control diet (CD) groups 4 weeks prior to breeding and throughout gestation and lactation. After weaning, male progeny were placed on a chow diet until 8 weeks old, and then segregated into HFD or CD groups. At 20 weeks old, rats were evaluated in the Morris water maze, and markers of oxidative stress and inflammation were documented in brain. In comparison to rats fed CD, cognitive decline in HFD progeny from HFD dams manifested as a decline in retention, but not acquisition, in the water maze. HFD was also associated with significant increases in 3-nitrotyrosine, inducible nitric oxide synthase, IL-6, and glial markers Iba-1 and GFAP, with the largest increases frequently observed in HFD animals born to HFD dams. Thus, these data collectively suggest that HFD increases oxidative and inflammatory signaling in brain, and further indicate that maternal HFD consumption might sensitize offspring to the detrimental effects of HFD.
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影响因子：
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通讯作者：
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影响因子：
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