Sex differences in gastric alcohol dehydrogenase activity in Sprague-Dawley rats.
Sex differences in gastric alcohol dehydrogenase activity in Sprague-Dawley rats.
复制标题
斯普拉格-道利大鼠胃醇脱氢酶活性的性别差异。
DOI：
10.1016/0016-5085(92)91438-a
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发表时间：
1992
期刊：
影响因子：
29.4
通讯作者：
Potter,JJ
中科院分区：
文献类型：
--
作者：
Mezey,E;Sharma,S;Rennie,L;Potter,JJ
在 Sprague-Dawley 大鼠中测定了性别差异和禁食对胃乙醇脱氢酶活性的影响。雌性大鼠的胃醇脱氢酶活性和酶蛋白水平高于雄性大鼠。卵巢切除术和睾丸切除术对乙醇脱氢酶没有影响，也没有改变酶活性的性别差异。禁食使雌性大鼠的酶活性降低程度高于雄性大鼠，从而消除了性别差异。雌性大鼠的血清胃泌素水平在禁食时下降，并在重新喂食后 24 小时内恢复到正常水平。对禁食和进食的雌性大鼠短期和长期施用五肽胃泌素不影响酶活性或酶蛋白水平，除了在施用禁食脂肪后12小时酶活性短暂增加但酶蛋白水平不增加之外。奥美拉唑可增加血清胃泌素水平并降低酶活性，但不会降低酶蛋白水平，被发现是该酶的竞争性抑制剂，Kiof 0.40 mmol/L。大鼠胃乙醇脱氢酶活性的性别差异和禁食变化的机制仍不清楚。
The effects of sex differences and of fasting on gastric alcohol dehydrogenase activity were determined in Sprague-Dawley rats. Gastric alcohol dehydrogenase activity and enzyme protein levels were higher in female than in male rats. Ovariectomy and orchiectomy had no effect on alcohol dehydrogenase and did not alter the sex difference in enzyme activity. Fasting decreased the enzyme activity more in female than in male rats, abolishing the sex difference. Serum gastrin levels measured in female rats decreased on fasting and returned to normal levels within 24 hours of refeeding. Shortand long-term administration of pentagastrin to fasted and fed female rats did not affect the enzyme activity or enzyme protein level, except for a transient increase in enzyme activity but not in enzyme protein level 12 hours after administration to fasted fats. Omeprazole, which increased serum gastrin levels and decreased enzyme activity but not enzyme protein levels, was found to be a competitive inhibitor of the enzyme with a Kiof 0.40 mmol/L. The mechanisms for the sex differences and changes with fasting in rat gastric alcohol dehydrogenase activity remain unknown.
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