Effects of CCK-8 on the reinstatement of morphine-induced CPP and expression of behavioral sensitization in rats
Effects of CCK-8 on the reinstatement of morphine-induced CPP and expression of behavioral sensitization in rats
复制标题
CCK-8对吗啡诱导的大鼠CPP恢复及行为敏化表达的影响
DOI：
10.1016/j.neuroscience.2013.02.057
复制
发表时间：
2013-05
期刊：
影响因子：
3.3
通讯作者：
Cong Bin
中科院分区：
文献类型：
--
作者：
Wen Di;Zang Guoqing;Sun Donglei;Yang Shengcheng;Yu Feng;Li Shujing;Ma Chunling;Cong Bin
八肽胆囊收缩素（CCK-8）是一种神经肽，在吗啡依赖和多种成瘾行为中起重要作用。我们以前曾报道CCK-8可减弱吗啡诱导的条件性位置偏爱（CPP）的获得，但CCK-8在药物复吸中的可能作用尚不清楚。在这里，我们评估了CCK-8对吗啡诱导的CPP和行为敏化的恢复的影响。单次注射0.1和1 μg CCK-8（i. c. v.）显著减弱药物（吗啡）和应激（足电击）引发的CPP恢复，并在恢复试验中降低升高的运动活性。此外，CCK-8阻断吗啡诱导的行为敏化的表达。但单独给予CCK-8（0.01、0.1和1 μg）不能使吗啡预处理大鼠CPP恢复，对足电击阈值敏感性也无明显影响。本研究结果显示CCK-8对复吸行为有明显的抑制作用，并为药物复吸的治疗提供潜在的应用。
Cholecystokinin octapeptide (CCK-8), a neuropeptide, plays an important role in morphine dependence and several addictive behaviors. We have previously reported that CCK-8 attenuates the acquisition of morphine-induced conditioned place preference (CPP), but the possible functions of CCK-8 on drug relapse remain unclear. Here we evaluated the effects of CCK-8 on the reinstatement of extinguished morphine-induced CPP and behavioral sensitization. A single injection of 0.1 and 1 μg CCK-8 (i.c.v.) significantly attenuated both drug- (morphine) and stress- (foot shock) primed reinstatement of CPP and reduced the escalated locomotor activity in reinstatement tests. Additionally, CCK-8 blocked the expression of morphine-induced behavioral sensitization. However, administration of CCK-8 (0.01, 0.1 and 1 μg) alone to morphine-pretreated rats could not trigger reinstatement of CPP and had no significant effect on threshold sensitivity to foot shock. In conclusion, our study identifies a distinct inhibitory effect of CCK-8 on the reinstatement of drug-seeking behavior and provides a potential application to the medication of drug relapse.
登录
查看更多内容
影响因子：
4.8
作者：
Stengel, Andreas;Goebel, Miriam;Wang, Lixin
通讯作者：
Wang, Lixin
影响因子：
4.1
作者：
F. Frenois;C. Moine;M. Cador
通讯作者：
F. Frenois;C. Moine;M. Cador
影响因子：
2.5
作者：
I.J.M. Beresford;M. D. Hall;C. Clark;R. Hill;J. Hughes
通讯作者：
I.J.M. Beresford;M. D. Hall;C. Clark;R. Hill;J. Hughes
影响因子：
2.9
作者：
T. Moran;P. Robinson;M. Goldrich;P. McHugh
通讯作者：
T. Moran;P. Robinson;M. Goldrich;P. McHugh
CCK-8S 对 GABA 诱导的大鼠背根神经节去极化的调节作用
影响因子：
2.9
作者：
Ma, Ke-Tao;Si, Jun-Qiang;Zhu, Li
通讯作者：
Zhu, Li