PIG--the pathogen interaction gateway.

PIG--the pathogen interaction gateway.
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DOI:
10.1093/nar/gkn799
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发表时间:
2009-01
影响因子:
14.9
通讯作者:
Sobral BW
Sobral BW
中科院分区:
生物学2区
文献类型:
--
作者:
Driscoll T;Dyer MD;Murali TM;Sobral BW

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蛋白质-蛋白质相互作用(PPI)在许多病原体的感染启动中起着至关重要的作用。确定哪些相互作用允许病原体感染其宿主可以帮助我们了解发病机制的方法,并为治疗提供潜在的靶点。用于研究宿主-病原体系统,特别是PPI的公共资源很少。为了促进宿主-病原体PPI的研究,我们从许多公共资源中收集并整合了宿主-病原体PPI(HP-PPI)数据,以创建病原体相互作用网关(PIG)。PIG提供了一个基于文本的检索和一个BLAST接口,用于检索HP-PPI数据。PIG中的每个条目包括诸如功能注释和存在于相互作用蛋白质中的结构域的信息。PIG提供了与外部数据库的链接,以便在各个网站之间轻松导航。此外,PIG还包括一个可视化单个HP-PPI网络或两个HP-PPI网络的工具。PIG可以在http://pig.vbi.vt.edu上访问。
Protein–protein interactions (PPIs) play a vital role in initiating infection in a number of pathogens. Identifying which interactions allow a pathogen to infect its host can help us to understand methods of pathogenesis and provide potential targets for therapeutics. Public resources for studying host–pathogen systems, in particular PPIs, are scarce. To facilitate the study of host–pathogen PPIs, we have collected and integrated host–pathogen PPI (HP–PPI) data from a number of public resources to create the Pathogen Interaction Gateway (PIG). PIG provides a text based search and a BLAST interface for searching the HP–PPI data. Each entry in PIG includes information such as the functional annotations and the domains present in the interacting proteins. PIG provides links to external databases to allow for easy navigation among the various websites. Additionally, PIG includes a tool for visualizing a single HP–PPI network or two HP–PPI networks. PIG can be accessed at http://pig.vbi.vt.edu.
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发表时间: 2006-01-01
影响因子: 14.9
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