MvirDB--a microbial database of protein toxins, virulence factors and antibiotic resistance genes for bio-defence applications.
MvirDB--a microbial database of protein toxins, virulence factors and antibiotic resistance genes for bio-defence applications.
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DOI：
10.1093/nar/gkl791
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发表时间：
2007-01
影响因子：
14.9
通讯作者：
Slezak T
中科院分区：
文献类型：
--
作者：
Zhou CE;Smith J;Lam M;Zemla A;Dyer MD;Slezak T
毒素，毒力因子和抗生素抗性基因的知识是必不可少的生物防御应用程序，旨在确定“功能”的特点新兴或工程病原体的签名。基因特征识别病原体，而功能特征识别病原体的能力。为了便于快速识别序列和表征基因的签名发现，我们已经收集了所有公开可用的（截至本文撰写时），有组织的序列代表已知的毒素，毒力因子和抗生素抗性基因在一个方便的数据库中，我们相信这将是有用的生物防御研究社区。MvirDB整合了来自Tox-Prot、SCORPION、PRINTS毒力因子、VFDB、TVFac、Islander、ARGO和维达亚类的DNA和蛋白质序列信息。MvirDB中的文件被超链接回其原始来源。blast工具允许用户对MvirDB中的所有DNA或蛋白质序列进行blast，浏览器工具允许用户搜索数据库以检索毒力因子描述、序列和分类，并下载感兴趣的序列。MvirDB具有每周自动更新机制。MvirDB中的每个蛋白质序列都使用我们的全自动蛋白质注释系统进行注释，并链接到该系统的浏览器工具。MvirDB可以访问。
Knowledge of toxins, virulence factors and antibiotic resistance genes is essential for bio-defense applications aimed at identifying ‘functional’ signatures for characterizing emerging or engineered pathogens. Whereas genetic signatures identify a pathogen, functional signatures identify what a pathogen is capable of. To facilitate rapid identification of sequences and characterization of genes for signature discovery, we have collected all publicly available (as of this writing), organized sequences representing known toxins, virulence factors, and antibiotic resistance genes in one convenient database, which we believe will be of use to the bio-defense research community. MvirDB integrates DNA and protein sequence information from Tox-Prot, SCORPION, the PRINTS virulence factors, VFDB, TVFac, Islander, ARGO and a subset of VIDA. Entries in MvirDB are hyperlinked back to their original sources. A blast tool allows the user to blast against all DNA or protein sequences in MvirDB, and a browser tool allows the user to search the database to retrieve virulence factor descriptions, sequences, and classifications, and to download sequences of interest. MvirDB has an automated weekly update mechanism. Each protein sequence in MvirDB is annotated using our fully automated protein annotation system and is linked to that system's browser tool. MvirDB can be accessed at .
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影响因子：
14.9
作者：
Mantri, Y;Williams, KP
通讯作者：
Williams, KP
影响因子：
14.9
作者：
Albà MM;Lee D;Pearl FM;Shepherd AJ;Martin N;Orengo CA;Kellam P
通讯作者：
Kellam P
影响因子：
1.9
作者：
Scaria J;Chandramouli U;Verma SK
通讯作者：
Verma SK
影响因子：
14.9
作者：
Chen L;Yang J;Yu J;Yao Z;Sun L;Shen Y;Jin Q
通讯作者：
Jin Q
影响因子：
2.8
作者：
Srinivasan, KN;Gopalakrishnakone, P;Brusic, V
通讯作者：
Brusic, V