Zebrafish as a Successful Animal Model for Screening Toxicity of Medicinal Plants.
Zebrafish as a Successful Animal Model for Screening Toxicity of Medicinal Plants.
复制标题
DOI：
10.3390/plants9101345
复制
发表时间：
2020-10-12
期刊：
影响因子：
--
通讯作者：
Lim V
中科院分区：
文献类型：
--
作者：
Chahardehi AM;Arsad H;Lim V
斑马鱼（Danio rerio）被用作胚胎和幼体模型进行体外实验和发育毒性研究。斑马鱼可用于在早期筛选测定中确定样品的毒性，通常以高通量方式。斑马鱼胚胎毒性模型是毒理学研究的前沿，因为分析所需时间短，胚胎透明，生命周期短，生育力高，遗传数据相似。斑马鱼毒性研究的范围从评估生物活性化合物或植物粗提物的毒性到确定最佳工艺。大多数研究的提取物是极性的，如乙醇、甲醇和水溶液，用于检测毒性和生物活性。本文综述了利用斑马鱼作为研究模型的最新研究，并强调了其作为检测药用植物毒性的工具的能力及其在提高对新药产生的理解方面的有效性。这篇综述的目的是建立一个与斑马鱼民族药理学研究的联系，以供其他研究人员进行未来的研究。
The zebrafish (Danio rerio) is used as an embryonic and larval model to perform in vitro experiments and developmental toxicity studies. Zebrafish may be used to determine the toxicity of samples in early screening assays, often in a high-throughput manner. The zebrafish embryotoxicity model is at the leading edge of toxicology research due to the short time required for analyses, transparency of embryos, short life cycle, high fertility, and genetic data similarity. Zebrafish toxicity studies range from assessing the toxicity of bioactive compounds or crude extracts from plants to determining the optimal process. Most of the studied extracts were polar, such as ethanol, methanol, and aqueous solutions, which were used to detect the toxicity and bioactivity. This review examines the latest research using zebrafish as a study model and highlights its power as a tool for detecting toxicity of medicinal plants and its effectiveness at enhancing the understanding of new drug generation. The goal of this review was to develop a link to ethnopharmacological zebrafish studies that can be used by other researchers to conduct future research.
登录
查看更多内容
影响因子：
--
作者：
Bambino K;Chu J
通讯作者：
Chu J
影响因子：
3.7
作者：
Ali S;van Mil HG;Richardson MK
通讯作者：
Richardson MK
影响因子：
0.9
作者：
Dang Thi Hoai Thanh;Nguyen Lai Thanh;Nguyen Dinh Thang
通讯作者：
Nguyen Dinh Thang
影响因子：
8.8
作者：
Chen, Yau-Hung;Yang, Zhi-Shiang;Shih, Tzenge-Lien
通讯作者：
Shih, Tzenge-Lien
DOI：
10.1155/2019/3807207
发表时间：
2019-01-01
影响因子：
--
作者：
Alafiatayo, Akinola Adekoya;Lai, Kok-Song;Shaharuddin, Noor Azmi
通讯作者：
Shaharuddin, Noor Azmi