Protection and Repair of Inner Ear Sensory Cells
Protection and Repair of Inner Ear Sensory Cells
复制标题
内耳感觉细胞的保护和修复
DOI：
10.1007/978-0-387-73364-7_6
复制
发表时间：
2008
期刊：
影响因子：
2.8
通讯作者：
T. Water
中科院分区：
文献类型：
--
作者：
A. Forge;T. Water
内耳的感觉毛细胞检测由声音（在耳蜗中）或头部位置的运动和变化（在前庭系统中）产生的机械刺激，并将其转化为神经信号。信息被传递到膜迷路的适当传入神经元复合体，然后传递到中枢神经系统的听觉和前庭束。这种外部感觉和机械刺激的翻译和传递是内耳及其感觉神经节的基本功能。内耳感觉感受器细胞（毛细胞）及其神经节的功能丧失会导致听力和平衡障碍。开发有效的治疗方法来预防这些感觉缺陷的发展需要更好地理解感觉毛细胞及其初级神经元损失的分子机制，以及内耳内的保护和修复机制。本章回顾了目前对内耳毛细胞和神经元损伤如何导致其死亡以及暴露于创伤剂后如何促进其存活的理解。耳和神经保护策略的有效性，以防止损伤的毛细胞和神经元的损失，从创伤内耳提出和讨论。
Sensory hair cells of the inner ear detect mechanical stimuli produced by sound (in the cochlea) or by motion and changes in head position (in the vestibular system) and translate them into neural signals. The information is transferred to the appropriate afferent neuronal complexes of the membranous labyrinth and then to the auditory and vestibular tracts of the central nervous system. This translation and transfer of external sensory and mechanical stimuli is the essential function of the inner ear and its sensory ganglia. Loss of function of the inner ear sensory receptor cells—the hair cells—and of their ganglia results in disorders of hearing and balance. The development of effective therapies to prevent the development of these sensory deficits requires a better understanding of the molecular mechanisms that underlie loss of sensory hair cells and their primary neurons, and of protection and repair mechanisms within the inner ear. This chapter reviews the current understanding of how injury to hair cells and neurons in the inner ear leads to their death and of how their survival after exposures to traumatizing agents might be promoted. The efficacy of otoand neuroprotective strategies to prevent the loss of injured hair cells and neurons from traumatized inner ears are presented and discussed.
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影响因子：
5.5
作者：
Marcus, DC;Wu, T;Kofuji, P
通讯作者：
Kofuji, P
DOI：
10.1002/neu.10002
发表时间：
2002-02-05
期刊：
JOURNAL OF NEUROBIOLOGY
影响因子：
--
作者：
Gale, JE;Meyers, JR;Corwin, JT
通讯作者：
Corwin, JT
影响因子：
--
作者：
RAPHAEL, Y;ALTSCHULER, RA
通讯作者：
ALTSCHULER, RA
DOI：
10.1073/pnas.97.22.11722
发表时间：
2000-10-24
影响因子：
11.1
作者：
Baird, RA;Burton, MD;Naeger, RA
通讯作者：
Naeger, RA
影响因子：
3.8
作者：
McFadden, SL;Ding, DL;Salvi, RJ
通讯作者：
Salvi, RJ